With advancing of the Century of Biology, it is deemed more and more important for protecting biological inventions by patent law. With reference to several international and local conventions and American cases, this paper analyses patentability of biological inventions and its moral limitation. After dealing with the general matters of patentability of biological inventions, the paper focuses on patentability of DNA sequence, and at last, it describes moral limitation to patenting biological inventions. The paper holds that, it is necessary for patent law to balance between protecting biological researches and biological industry and maintaining social morals, ethics and life dignity.