The purposes of this study were (1)to develop the quality of family life questionnaire through reliability and validity tests, (2)to understand the current quality of family life outcomes of students in home-based programs, (3)to determine the latent constructs related to quality of family life outcomes of students in home-based programs in Taiwan. Quantitative and qualitative research methods were used to study families whose severely/profoundly or multiply disabled children were in the home-based programs. Data were gathered through questionnaires interviews. A total of 307 parents and 22 home-based itinerant teachers were participated in the study. Family in the context of quality of life were examined using a theoretical family systems model. Descriptive themes and issues emerged from the data that leaded to a greater understanding of what families faced when their severely/profoundly disabled children were in the home-based programs. The data helped families and professionals work in partnership to improve the quality of life for children with sever/profound disabilities. The themes and issues were discussed and implications for future services and research were presented.