Taiwan devotes itself into culturing biotechnology industry by laying groundwork of competitive advantage of nation. Most useful arts then would be produced and transferred preponderantly from academic research institute due to the factors of technique itself, environment and governmental policies. This phenomenon makes research activities conducted in these institute being use-for-profit, but not non-profit anymore. Research exemption rule thus can’t provide protection of them. Based on the results of economic analysis, for the purposes to avoid the transaction cost being such high that hindering the progress of science, to increase the positive externality and the supplement of knowledge, and also to prevent resources form under-use. This article suggests that the scope of research exemption should be broadened in order to separate “knowledge information” in the area of R&D from “useful arts” in the area of commerce. By doing this, the information utilized in, only in, R&D area will be still public goods as usual and the rest information falls into quasi-public goods if it meets the criteria of useful arts.