The purpose of this research was to explore the stress coping process of six college students with disabilities based on Lazarus and Folkman’s theory of stress appraisal and coping. The participants were four males and two females, among which three were visually impaired, two had physical disability and one had hearing impairment. The qualitative research method was employed and the data was gathered by in-depth interviews, personal documents and reflective journals. The results indicated that the main stress events the participants encountered in their college life included four domains: academic, future plan, interpersonal relationship and family. The cognitive appraisals of the different stress events the participants explicated were hurt, loss, threat, challenge, conflict, overload and ambiguity or two or more of the above. The attributes of the coping strategies adopted included: active coping, making plan, seeking social supports, redefining the situation, accepting the fact, expressing the emotion and escaping. The conclusions of the participants’ stress coping outcomes showed that different participants using the same strategies might cause different outcomes. Social support has the positive function. When the participants predicted that they couldn’t control the outcomes well, they generally adopted passive coping strategies. When the participants think that the event was caused by their disabilities, they generally appraised it as a stressful event. Obviously different kinds of disabilities were associated with different aspects of stress coping. And if the participants lacked of social skills, they usually had the stress on interpersonal relationship. If they couldn’t achieve the expectations, it would cause stress. Finally, if they had good social support systems, it could reduce their stress. The results showed that different participants adopting the same strategies might cause different coping outcomes. However, searching social support always resulted in positive outcome. If the coping outcomes were negative, the individual’s life adjustment would be affected. Finally, the specific personal and the environmental factors related to the stress coing processes of each participant were discussed in this study.