ADH2及ALDH2基因對酒癮所扮演的角色__臺灣人文及社會科學引文索引資料庫

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題名：	ADH2及ALDH2基因對酒癮所扮演的角色
書刊名：	臺灣精神醫學
作者：	陸汝斌
作者(外文)：	Lu, Ru-band
出版日期：	2003
卷期：	17:4
頁次：	頁248-262
主題關鍵詞：	乙醇去氫酶；乙醛去氫酶；基因；酒癮；ADH；ALDH；Gene；Alcoholism
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(1) 博士論文(1) 專書(0) 專書論文(0) 排除自我引用:1 共同引用:0 點閱:46

　　　　　近年來分子遺傳學快速的發展，一些主要的精神疾病如精神分裂症、情感型精神病、酒精或物質濫用，甚至性格違常均發現遺傳為主要的致病原因之一，但這些高異質性又複雜遺傳機制的精神疾病，至今尚未確定找到其致病基因。然而在諸多與精神疾病有關的候選基因中，當以ADH2及ALDH2基因與酒癮的關係最具一致性的結果，且在傳統�篨リW也得到部分的支持。本文即為回顧以往的研究報導及近年來本研究小組進一步的探討，結果發現若將酒癮分為不同的亞型，僅焦慮—憂鬱型酒癮ADH2、ALDH2基因將可能與DRD2基因交互作用而影響飲酒行為，以致成為酒癮，若在監獄中取樣反社會人格違常合併酒癮之案例則發現，反社會人格違常可抑制ADH22對偶基因，甚至可能同時減低ALDH22對偶基因對酒癮的保護作用，因此不論分子遺傳學如何快速的進展，若不能配合臨床分類、亞型等表現型的發展，及在取樣上能更廣泛以各種不同樣本反覆驗證，可能並不能完全由分子遺傳學的結果有效解釋臨床上的發現，換言之，即使是以往已認定的假設或理論在分子遺傳學的快速發展下，仍值得以這些新的知識及工具配合臨床更精確的分類及取樣，作進一步的驗證及探討。

以文找文

　　　　　Along with the rapid development of molecular genetics, several major mental diseases such as schizophrenia, affective disorders and substances abuse or even personality disorders are found to have high genetic components. Until today, the actual gene etiology is not yet assuredly identified because of the highly heterogeneous and complex genetic mechanisms of these mental diseases. Among the several mental-illness related candidate genes, ADH2 and ALDH2 have the most consistent results as relating them to the development of alcoholism. These results are also partly supported by the enzymatic studies. The article reviewed the past literatures and our team's studies of recent years. We found that only in the anxiety-depression subtype of alcoholism, ADH2 and ALDH2 genes may interact with DRD2 gene to influence drinking behavior and then affect the development of alcoholism. We also found that antisocial personality disorder may inhibit ADH22 allele and even reduce the alcoholism-protection effect of ALDH22 allele when we sampled the subjects of antisocial personality disorder with or without alcoholism from jails. Therefore even molecular genetics progress rapidly, it may not effectively explain the finding results unless the phenotype of the clinical findings and the subtypes of mental illnesses can be applied into the studies and examined repeatedly and comprehensively by different samples. In other words, even the well-accepted hypotheses or theories developed by the previous molecular genetics can be still further examined and researched by our new knowledge and tools of accurate categorization and sanpling methods.

以文找文

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學位論文
1.	蔡循珣(2002)。酒癮患者在不同族群ADH22和ALDH22基因型之分子遺傳學探討，Republic of China。延伸查詢

圖書
1.	American Psychiatric Association(1994)。Diagnostic and Statistical Manual of Mental Disorder: DSM-IV。Washington, D.C.：American Psychiatric Association。
2.	尹士俊(1996)。Alcohol Dehydrogenase: Enzymology and Metabolism。The Biology of Alcohol Problems。Oxford。
3.	Tipton, K. F.、Henehan, G. T.、Harrington, M. C.(1989)。Cellular and Intracellular Distribution of Aldehyde Dehydrogenases。Human Metabolism of Alcohol (2)。Boca Raton, FL。
4.	Feldman, R. S.、Meyer, J. S.、Quenzer, L. F.(1997)。Pathways of Dopamine Catabolism。Principles of Neuropsychopharmacology。Sunderland, MA。

其他
1.	黃三原，林偉文，柯慧貞，李嘉富，Wang, T. J.，周元華，尹士俊，陸汝斌(2003)。Possible Interaction of ADH and ALDH Genes with Dopamine D2 Receptor (DRD2) Gene in Anxiety-depressive Alcohol Dependence，沒有紀錄。延伸查詢
2.	陸汝斌，柯慧貞，李嘉富(2003)。Antisocial Personality Disorder May Inhibit the Alcoholism-protection Effects of ADH22 and ProbablyALDH22 among Han Chinese in Taiwan，沒有紀錄。

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