Background and Purpose: Performing medical interviews with bio-psycho-social (BPS) literacy is considered important, but so far no effective teaching methods are available. This action research attempted to determine if learning/assessment strategies using a medical interview organizer with cognitive mapping can help learners solve BPS problems during medical interviews. Methods: Amedical interview organizer, 2 sets of prompt questions, and the technique of cognitive mapping were introduced to medical students during their clinical rotation in family medicine. In a qualitative interpretive way, the authors observed, documented, and assessed the dialogue and interactions between 1 case student and the other participants (the teacher, a standardized patient, and fellow-student peers). Results: Increased knowledge construction and value clarification related to the BPS problems were observed as evidenced by the addition, interrelation, and deployment of components in cognitive maps. The medical interview organizer improved the case student's comprehension. The heuristic cognitive mapping and prompt questions helped the case students understand relationships of the information among the 3 BPS dimensions, and obtain good diagnostic outcomes from the medical interviews. Conclusions: Our design to teach medical students BPS medical interview skills is practical and effective. The interview organizer is useful to obtain clinical data in BPS dimensions; the use of cognitive mapping and small group discussion are useful to teach BPS medical interview skills.