目的：了解精神分裂症門診病患的藥物結盟行為和主要照顧者的特性及家庭功能的關係。方法：採用相關性研究設計，使用結構性問卷，以立意取樣方式，訪談北部某醫學中心精神科門診的精神分裂症病患及其家屬共七十對，再將資料做描述性及相關性分析。結果：主要照顧者沒有宗教信仰者、沒有超自然疾病歸因者、與病患相處時間較少者、對藥物種類認知越少、對藥物顆數的認知越多者，其所照顧之精神分裂病患藥物結盟行為較好。在家庭功能部份，家人處理不規則服藥的效能越高時，使用心理支持處理副作用的頻率越高時，精神分裂病患藥物結盟行為較好。結論：在社區精神分裂症病患的藥物治療中，了解主要照顧者對治療的信念、認知及特殊家庭功能是非常重要的，因為如此方能將主要照顧者納入醫療團隊中，了解他們對藥物治療的疑慮，協助他們在社區中監測病人，使其能持續接受規則的藥物治療。

　　　　　Objectives: The objectives of this research were to understand the relationships between the drug alliance behaviors of schizophrenic outpatients and characteristics of key persons and family functions. Methods: We used correlation study with structured questionnaires interviewed 70 schizophrenic outpatients and families pairs from the Psychiatric Department of a medical center in northern. Results: The results showed that better drug alliance behaviors were found in patients whose key persons did not believe in supernatural causes of disease, did not have religious beliefs, spent little time with the patients each day, and had a limited understanding of drug types and, had a better understanding of drug dosage. If the families effectively enable patients to take medication regularly and to use mental support frequently to manage side effects of medication, the drug alliance behaviors were better. Conclusion: It is important to understand the key persons?beliefs about treatments and the special role of family function in medication therapy. By this way, we can incorporate the key persns in medical teams, understand their problems, and help them to monitor patients to follow treatments properly.