Industry-University Cooperation means that the professors lead their students to improve processes, develop new products, and promote techniques in enterprises and obtain rewards. The Industry-University Cooperation becomes new tendency in higher education. Recently there are so much effects by Industry-University Cooperation during last years. The universities may feed back to our society with Industry-University Cooperation by their abundant knowledge and technology. Our society have more expectations to professional and technological education, the relationship will become rigidly precise between them and community. Especially the Department of industrial safety and hygiene have the responsibilities to cultivate the labor safety and health personnel, not only for industry or hospitals, but also for every occupation. But there are so many enterprise have no ability to improve the safety conditions, and the other hand, the students major in occupational safety and hygiene have no factories to practice what they has been taught. We try to introduce the Industrial Safety Strategic Alliance with Industry-University Cooperation in order to make a good relationship between the Departments of Occupational Safety and Hygiene and their neighbor factories. Then we use a case to illustrate how to set up and operate the Industrial Safety Strategic Alliance. At last we also analysis the possible difficulties and make some suggestions.