Gout is one of the most common forms of joint inflammation which is caused by deposit of urate crystals. It appears as an acute attack and often develops with joint damage, disability and chronic diseases. Gout affects mostly men and researches recently indicate that young gout patients are more and more. Purposes of this study were to examine the knowledge, attitudes and preventive behaviors on gout among middle-aged male adults in Kaoshiung and Petung area. Factors influencing gout knowledge were also considered. Results showed that subjects had better cognition about “acute attack of gout invoives joint inflammation, swelling and severe pain”. and “Exercise and weight control can reduce incidence of gout”. Subjects had worse recognition of “hyperuricaemia patients should have diet restriction of purine”. Most participants' attitudes toward the disease prevention were positive, but they don't think they will suffer from gout arthritis. About preventative behaviors, subjects did more weight and alcohol control, but less intake of purine food. Subjects who have family members with gout had more positive attitude and unhealthy subjects had worse knowledge toward the disease. Knowledge, attitude and behaviors had significant relationships. We concluded that health activities and education program for preventing gout are needed and should be promoted.