In this article, I explore the philosophical itinerary of the notion of ‘soul’ in western philosophy. Part I places special emphasis on the Aristotelian-Thomistic account of soul, explaining it in light of four key background issues: ‘act and potency’, ‘matter and form’, Aristotelian four-dimensional causality, and the teleological ‘cosmos’. I then explain the demise of the Aristotelian-Thomistic account occasioned by the rejection of the notions of final and formal causality, and intellectual event of paramount significance in western thought originating in William of Ockham and culminating in René Descartes. In part II, I consider mainstream western philosophy’s abandonment of the notion of ‘soul’ altogether along with Cartesian dualism, and how this abandonment marked the intellectual itinerary of the philosophy of mind which would endeavor to resolve the mindbody problem entirely bereft of anything approaching a classical conception of ‘soul’. In this context, I briefly spotlight the work of John Searle on the problem of consciousness. In part III, I consider the Aristotelian-Thomistic account of the human soul on greater detail, especially five of its central (and most misunderstood) features: the soul as substantial form of the body, as not superimposed on the body; as intellective and incorporeal; as an incomplete substance considered in itself; and the soul-body communion as constitutive of the substantial reality which is the human person. In the conclusion, the substantial reality which is the human person. In the conclusion, I ask whether contemporary science can dialogue with the Aristotelian-Thomistic account of the human soul. I answer that his can only take place if science is willing to countenance the possibility of non-physical causal pathways, and to genuinely re-revaluate the notion of formal causality. I further conclude that endorsement of the Aristotelian hylemorphic conception of ontological composition opens the possibility to sustaining mental realism and anti-reducationism while avoiding commitments to substance dualism or property dualism, all the while rejecting material monism.