The purpose of ethic practice is to lead a good life. And happiness (??δαιμ?ν?α, eudaimonia in Greek and beatitude in Latin), "the best, the noblest and the most joyful thing in the world" in Aristotle's eyes, is the all-inclusive term of such a life. As the last end of life, "happiness" is inevitably one of the central concepts of philosophical ethics. Through Thomas Aquinas's views about "happiness," which is to focus on the subject of ethical practice-human persons, we discuss in details "what men's/women's happiness is." First, we employ Aquinas's negative methodology to rule out the things that don't qualify as happiness; then we will suggest in an analytical and dialectical way what qualifies as happiness for men/women, in wishes to answer the essential question: "What is happiness?" This can be one of the concepts on which to construct the Fu-Jen School's last end of life.