The current study is structured in two parts and partially inquired into the neurobiology scientist proposed ”new human image”: In the first part, ”the new human image” which the author discusses the neurobiological science proposed. The second part, the author inspects neurobiology challenge whether it does succeed. The author proposes three main points: The mental phenomenon is unable to reduce to the physical phenomenon; the limbic system is unable completely to control the will action; the self is not the cerebrum, the self is one sociality and the culture constructs.