本研究以DeLone and McLean (2003) 的資訊系統成功模型為基礎，透過相關文獻探討，發展出知識管理系統成功模型。本研究以台灣某醫學中心員工共153份有效問卷為研究對象，運用結構方程模式驗證實徵資料與理論模型之契合度，研究結果發現：(1) 本研究所提出之知識管理系統成功模型與實徵資料檢測之後，證實在醫療產業環境脈絡下，具有良好之模型契合度，顯示本模型具極佳之理論穩健性與實務適用性；(2) 信任確為影響知識管理系統使用與使用者滿意之重要直接前因變項，其影響力甚至超過系統品質、資訊品質、服務品質；(3) 信任也是系統品質、資訊品質、服務品質與使用、使用者滿意之間的重要中介變項；(4) 本研究確認算計為基礎的信任、制度為基礎的信任、知識為基礎的信任為組成信任三個重要的子構面，三者並具相當良好之區別效度；(5) IS部門的服務品質對於系統品質與資訊品質的提升具有顯著的正向影響；(6) 根據結構方程模式契合度之比較，本研究模型較原DeLone and McLean (2003) 之資訊系統成功模型之模型契合度為優。 本研究的結果提示營造組織內部信任氛圍在知識管理系統成功之重要性，實證的結果與意涵可提供醫療院所發展配套激勵方案之參考。

Based on D&M IS Success Model (DeLone and McLean, 2003), the research aims at a medical center in Taiwan to develop the success model of knowledge management systems (KMS Success Model). Using Structural Equation Modeling (SEM), the proposed hypotheses is to verify the fit of empirical data and model. The conclusions are: (1) According to the statistical results, the proposed success model fits very well for the 153 samples of the medical center. (2) Trust is the most important antecedent of system use and user satisfaction. (3) The effects of system quality, information quality and service quality on system use and user satisfaction are mediated by trust. (4) All of the three dimensions of trust: calculative-based trust, institution-based trust and knowledge-based trust have significant influences on trust. (5) Service quality of IS departments has positive significant influences on system quality and information quality. (6) In general, the overall model fits’ indices of KMS Success Model are better than D&M IS Success Model.