Human knowledge begins with sense experience. The direct contact of the sense organ brings about mental activities which result in the formation of images or concepts. What is formed within the mind is expressed without the mind through language; hence there is a connection between, thought, language and being. Predication is the mental activity that uses one term to express the other. In predication, the mind has first to integrate all the different elements and make them into one concept. In predication however, activity is carries out in the opposite direction where the mind resolves the whole into parts. Consequently, there are different levels of predication. The purpose of this paper is to investigate the relation between logical predication and metaphysical predication, and reflect on the relation between metaphysics and predication. It is divided into three parts: (1) the origin of the concept of predication and its meaning; (2) the relation between predication and scientific knowledge; (3) the relation between predication and metaphysics.