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題名：Mannitol引起的急性腎衰竭--案例報告
書刊名：臺灣臨床藥學雜誌
作者：張美惠／蔡春玉／鄧新棠
作者(外文)：Chang, Mei-hui／Tsai, Chun-yu／Deng, Shin-tarng
出版日期：2005
卷期：13:2
頁次：頁63-74
主題關鍵詞：急性腎衰竭；藥物不良反應；Mannitol；Acute renal failure；Adverse drug reaction
原始連結：連回原系統網址new window
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本文報告一位84歲男性病患，因左側中腦動脈大範圍梗塞導致腦水腫，以mannitol降低顱內壓，使用63小時累積劑量225g後，發生急性寡尿腎衰竭，在排除其他藥品及可能導致急性腎衰竭的相關因素，並經由Naranjo “不良反;應與藥品相關性的評估”結果，認為極有可能是mannitol造成的急性腎衰竭，經停藥並施行位液透析治療後，病患尿量增加，腎功能回復。文中藉由案例報告及文獻資料回顧，探討mannitol造成急性腎衰竭的致病機轉、危險因子和處置方式以及預防的方法。
We report a 84-year-old man admitted due to left middle cerebral artery (MCA) large infarction with progressive effect. Mannitol was used to decrease cerebral edema. After receiving mannitol 225g during a time period of 63 hours, patient had an acute oligouria renal failure. Excluding other medications and diseases as causes of acute renal failure, it is probable that acute renal failure was caused by mannitol. Urine amount increased and renal function improved after discontinuation of mannitol and removal of mannitol by hemodialysis. The previous case reports and clinical literature on mannitol related acute renal failure, its potential mechanisms, risk factors, prevention and management were reviewed and discussed.
期刊論文
1.Bereczki, Daniel、Mihdlka, Laszlo、Szatmari, Szabolcs、Fekete, Klara、Di Cesar, David、Fulesdi, Bela、Csiba, Laszlo、Fekete, Istvan(2003)。Mannitol use in acute stroke。Stroke，34，1730-1735。  new window
2.Better, O. S.、Rubinstein, I.、Winaver, J. M.、Knochel, J. P.(1997)。Mannitol therapy revisited (1940-1997)。Kidney Int，52，886-894。  new window
3.Heinsius, T.、Bogousslavsky, J.、Van Melle, G.(1998)。Large infarcts in the middle cerebral artery territory. Etiology and outcome patterns。Neurology，50，341-350。  new window
4.Adams, H. P. Jr、Adams, R. J.、Brott, T.、Zoppo, G. J.、Furlan, A.、Goldstein, L. B.、Grubb, R. L.、Higashida, R.、Kidwell, C.、Kwiatkowski, T. G.、Marler, J. R.、Hademenos, G. J.(2003)。Guidelines for the early management of patients with ischemic stroke。Stroke，34，1056-1083。  new window
5.Manno, E. M.、Adams, R. E.、Derdeyn, C. P.、Powers, W. J.、Diringer, M. N.(1999)。The effects of mannitol on cerebral edema after large hemispheric cerebral infarct。Neurology，52，583-587。  new window
6.Grotta, J. C.(1987)。Current medical and surgical therapy for cerebrovascular disease。N Engl J Med，317，1505-1506。  new window
7.Bruno, A.(2002)。Admission glucose level andclinical outcomes in the NINDS rt-PA Stroke Trial。Neurology，59，669-674。  new window
8.Perez-Perez, A. J.、Pazos, B.、Sobradol, J.、Gonzalez, L.、Gandara, A.(2002)。Acute renal failure following massive mannitol infusion。Am J Nephrol，22，573-575。  new window
9.Goldwasser, P.、Fotino, S.(1984)。Acute renal failure following massive mannitol infusion appropriate response of tubuloglomerular feedback?。Archives of Internal Medicine，144，2214-2216。  new window
10.Horgan, K. J.、Ottaviano, Y. L.、Watson, A. J.(1989)。Acute renal failure due to mannitol intoxication。Am J Nephrol，9，106-109。  new window
11.Nakhoul, F.、Better, O. S.(1995)。Acute renal failure following massive mannitol infusion and enalapril treatment。Clinical Nephrology，44，118-120。  new window
12.Weaver, A.、Sica, D. A.(1987)。Mannitol-induced acute renal failure。Nephron，45，233-235。  new window
13.Lin, S. L.、Hung, K. Y.、Lin, Wu F. L.、Wei, S. C.、Wu, K. D.(1995)。Mannitol-induced acute renal failure。Nephrol Dial Transplant，10，120-122。  new window
14.Gadallah, M. F.、Lynn, M.、Work, J.(1995)。Case report: Mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanism。Am J Med Sci，309，219-222。  new window
15.Visweswaran, P.、Massin, E. K.、Dubose, T. D. Jr.(1997)。Mannitol-induced acute renal failure。J. Am. Soc. Nephrol，8，1028-1033。  new window
16.Dorman, H. R.、Sondheimer, J. H.、Cadnapaphornchai, P.(1990)。Mannitol-induced acute renal failure。Medicine，69，153-159。  new window
17.Kent, Doi、Ogawa, Naomi、Suzki, Etsu(2003)。Mannitol induced acute renal failure。Am. J. Med，115，593-594。  new window
18.Borges, H. F.、Hocks, J.、Kjellstrand, C. M.(1982)。Mannitol intoxication in patients with renal failure。Arch Intern Med，142，63-66。  new window
19.Rabetoy, G. M.、Fredericks, M. R.、Hostettler, C. F.(1993)。Where the kidney is concerned, how much mannitol is too much?。Annals of Pharmacotherapy，27，25-28。  new window
20.Sakemi, T.、Ikeda, Y.、Ohtsuka, N.(1996)。Acute renal failure associated with mannitol infusion and reversal with ultrafiltration and hemodialysis(letter)。Nephron，73，733-734。  new window
 
 
 
 
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