本研究探討不同劑量咖啡因對於青少年血壓之影響。方法：以19 位健康高 中男性青少年(平均年齡17.9±0.7 歲，平均身高173.5±5.6 公分，平均體重64.9±8.7 公斤)於不同時間，靜止並維持坐姿接受0mg(安慰劑)、100mg、200mg 及300mg 四種咖啡因劑量，並於咖啡因介入前與介入90 分鐘後量測受試者的手臂動脈血 壓值。結果：由分析結果得到，咖啡因攝取的劑量增加，受試者的收縮壓(由119±7 mm Hg 升至131±13 mm Hg)雖有提升，但沒有顯著增加；而舒張壓(由65±8 mm Hg 升至73±8 mm Hg)也有提升的趨勢，其中又以200mg、300mg 咖啡因介入後， 舒張壓平均上升4±7mm Hg 最為顯著。結論：本實驗結果指出，咖啡因攝取與 青少年血壓之提升有關，建議青少年在食用含有咖啡因含量的食物，建議以 200mg 為上限。

OBJECTIVE: The purpose of this study was to exam the effect of the caffeine intake to the blood pressure among adolescents. METHOD: Different dosages of caffeine ( 0 mg , 100 mg, 200 mg, and 300 mg) were administered orally to 19 healthy senior high school volunteers (age: 17.9 ± 0.7years; ht: 173.5 ± 5.6cm; wt: 64.9 ± 8.7 kg). The blood pressures [systolic blood pressure (SBP) and diastolic blood pressure (DBP)] were measured before and 90 minutes after the caffeine intervention. RESULTS: Although SBP was not significantly affected by different dosages of caffeine, but it had a tendency of increasing SBP when the dosage of caffeine intake increased; DBP was positively and significantly (p<0.05) affected by the different dosages of caffeine intake. After 200mg, 300mg caffeine intake, the DBP increased from 69±8 mm Hg to 73±6 mm Hg and 69±10 mm Hg to 73±8 mm Hg, respectively. CONCLUSIONS: Caffeine intake significantly increases DBP in healthy adolescents. Our finding suggested that the adolescents should not have to drink caffeine more than 200 mg daily.