Corruption is one of serious problems in the PRC. The damages of corruption have jeopardized the sovereignty of the Chinese Communist Party (CCP). Anti-Corruption now has got serious attention of CCP and carries “The Inner-Party Supervision Regulations of CCP” into execution. In fact, CCP already have many anti-corruption systems before the ISR. What China and CCP need is how to put the system into practice. Can the ISR make differences? This paper attempts to employ the mechanism design theory to analyze the design and exercise of ISR, investigating the informational efficiency and incentive compatibility, ISR can create, with a view to exploring the effects and developments ISR can reach in anti-corruption.