Although wine does not originate from Europe, it has been absorbed actually by the Europeans. After the Greeks, Romans and the French have cultivated the grapes, wine grew to be an essential part of European culture, and it began to hear a "sacred" meaning. In ancient times, wine once was a marvelous medicine with mysterious medicinal virtues. Because of the difficulty of wine manufacture and preservation, it was the ruling class's privilege to enjoy wine in early days. Today, the development of wine is beyond the imagination of their ancestors, Grape can be divided into as many as thousand kinds. As time went on, the type, the flavor and the value of wine varies in numerous ways. Almost everyone hear the name of the Greek philosopher-Aristotle, and his great saga, but few know he was the founder who integrated academic theory with technology related to the cultivation of grape and the amelioration of wine. We all know the historical importance of Alexander the Great, the "father of the medicine"-Hippocrates, Julius Caesar, Charlemagne, Louis XIV but we hear little about their important relation with the development of wine culture. This article is trying to theorize and systematize this important historical development of European wine culture. It hopes Taiwanese readers can transcend language barrier and get a good sight of European culture as a whole through their experiences in daily drinking.