Being part of the basis of human activities, economy is closely connected to the progress of human civilization. On the other hand, art museums carry by themselves the mission of inheriting human culture. Interestingly, they both are all closely related to human civilization, but they never interact with each other during their development process. Of which, the main reason is simply because the museum is by tradition against the commercial and economic operations. However, a subtle relationship between the art museum and economy has undergone a tremendous change in recent years. In the twenty-first century, the art museum was looking for new vitality by adopting economic principles. Suddenly the two parallel lines from the past began to intersec. However, art museum has a hard time getting rid of its prejudice against economy, a complex love mixed with hatred. This interesting new relationship led to a series of changes inside the museum and museum communities. The key issue of this study is to learn how the museum’s paradigm shifts from the traditional “art / academy’’ to a new “art/enterprise’’. By the research and analysis of different literatures, we find out the origin of the new paradigm, as well as its impact on art museums in the world.