In English speaking world, J.Dewey and A.N. Whitehead were two of the most renowned philosophers of process, who took nature as becoming process, highlighted the temporal, organic, and creative characters of reality, and asserted the immediacy, continuity, and spontaneity of physical and mental experiences. In addition, they both substituted the concept of ”function” for that of ”substance” in the status of traditional metaphysics and thereby had been considered as philosophers thinking process. However, it is noteworthy that Dewey, a great representative of American pragmatism, though having imbibed neo-Kantianism and neo-Hegelianism in the early stage of his philosophical development, directed his thought toward naturalism, skepticism, and empiricism and eventually became critical to theism and speculative philosophy. While Whitehead, though originally a mathematician and a logician, converted to philosophy and became an exponent of speculative philosophy and process metaphysics with a critical attitude to scientific materialism and its variations. With the belief that the role of God is indispensible in the construction of the modern worldview Whitehead suggested the alternative of panentheism other than theism and atheism. The remarkably contrasts between the two and their interactions after Whitehead's migration to America provide an interesting topic in our understanding the development of contemporary process philosophy and their contributions to the related issues.