Recently, the globalization expands the economic distance of urban and rural. Although the government strives to reach a balance between regional developments, however, there are still constant criticisms alleging more resources are allocated for the northern region, while less for the southern region. Create urban-rural gap between the quality of the living environment, and resources are mostly concentrated in northern Taiwan. Resulting population urbanization, making southern Taiwan and Northern Taiwan of the development is very different, and the government hopes that the use of regional development to promote regional industries and population distribution, and reducing regional development gap. The objective of this study is to analyze the population and employment of Taipei metropolitan area and Kaohsiung metropolitan area by "economic-based analysis" to provide for government policy-making. In the present study, regional economics theory and economics-based analysis method are explained first. Then using location quotient (L.Q.) to analyze of the basic industries in the metropolitan area, and population and employment multiplier of Taipei metropolitan area and Kaohsiung metropolitan area are analyzed by econometric method which is based on the study of the differences between Taipei metropolitan area and Kaohsiung metropolitan area by literature review. The results show that. (1) Two major metropolitan areas of basic industries in the past the original industrial or industrial transformation to a service-based business and services of the industry keep abreast of the times. (2) Metropolitan area employment situation of the population evolution of the phenomenon showed a widening gap. (3) By the employment multiplier effect analysis indicates that if the two major metropolitan areas by the development of basic industries led the region in total employment population, the Taipei metropolitan area should be developed commercial, transport storage and communication industry and other service industries, the Kaohsiung metropolitan area should be development commercial. (4) By the multiplier effect of the population tells us that if the two major metropolitan areas by the development of basic industries to stimulate regional total population, the Taipei metropolitan area should be the development of commercial, transport storage and communication industry and other service industries, the Kaohsiung metropolitan area should be development commercial.