The aim of this study was to analyze the impacts of the restraint protocol used by nurses in a coronary care unit (CCU). Method: We enrolled 135 patients with invasive catheterizations. Analyses were performed by SPSS. Results: Factors that affected nurses to perform the restraint techniques were the patient's Glasgow coma scale (GCS) score, communication ability, and the amount of invasive catheterizations. Conclusion: First, we suggested reinforcing nurses assessment of the necessity of restraints on patients who received more than 3 catheters and GCS scored<12.Second, if patients GCS scored≥12, we suggested that the staffs strengthen the patient's cognition of the catheter in communication and explain the importance of catheters. We expect that this study will provide nurses with a standard of nursing assessment before applying restraints on patients with multiple invasive catheterizations. The results may further promote the quality of restraint and lower the incidence of inappropriately using it.