Cruise travel has been winning the recognition in Asian within recent years. However, researches seldom target on related subjects of forecast for cruise travel demand. Tourism related investments take certain time and huge amount of funds, especially building costly cruises, the precise forecast tool plays the essential role to help reveal the quantity of demand and make the correct decisions of operation strategy. The MATLAB program code which applies Artificial Neural Network was developed to forecast cruise travel demand. All of the input variables were collected after surveying relative literatures, market analysis and evaluation, and numerical validation. It proves that this practical tool may provide the satisfying result for Hong-Kong and Taiwan cruise demand forecast.