The issues of the crisis management and emergency medicine disaster response have been emphasized as key elements in various levels of hospital organizations. In Taiwan, the hospital social workers have been involved in different types of disaster events in their hospitals, and have accumulated precious experiences. Through the author’s practical experiences and literature review, this paper will discuss the development and evolution process regarding the hospital-based disaster response and the intervention of social work profession,then the perspectives of the disaster medicine and crisis management will be used. The issues to be discussed are: (1) definitions of the disaster and disaster medicine related concepts; (2) the hospital-based disaster response types and social work intervention; (3) the hospital social workers’ roles and functions on disaster relief. Hope this paper may serve as a basis for further development on practices and academic investigation on disaster social work.