Abstract According to the Labor Inspection Annual Report of the Council of Labor Affairs, the occupational death rate of every 1000 people of the manufacturing industry in Taiwan is only lower than that of the construction industry, and the frequency of disabilities or injuries is the highest among all industries. Compared with other developed countries, including the USA, Japan and the UK, there are still improvements that the manufacturing industry should pay more attention to regarding labor health and safety. Referring to Heinrich’s accident pyramid theory, this study constructed a local occupational loss model based on the data of labor insurance benefit payment from the Council of Labor Affairs. The research results indicated that the ratio of death to disability to injury or illness due to occupational accidents for all industries in Taiwan is 1:6:69, and for the manufacturing industry it is 1:11:98. Furthermore, accident media, including pressurized containers, welding equipment and hazardous materials, etc., and fire, electrical accidents and drowning were found to cause more serious outcomes. Furthermore, if taking into account the post-accident labor insurance benefit payment, the high expenditure of accidents due to electric apparatus and fire or explosion are often neglected because these accidents do not happen frequently. Contrarily, for accidents caused by general powered machinery, transportation equipment, rolling-up or cuts, although they cost a lower amount of insurance benefit payments, happen much more frequently. Both of these two types of accidents deserve equal attention. However, shown in the yearly trend, the accident pyramid in Taiwan has not yet achieved stability, so continuous observation is suggested. Based on the model established in this study, labor insurance cash benefits and health benefits, and direct losses of occupational accidents can be estimated. Even the indirect loss calculation model and occupational accident loss estimation system for the manufacturing industry can be developed, providing relevant enterprises a way to control occupational accident losses.