Diabetes mellitus which controls blood glucose concentration is very important. Pharmacotherapy is able to improve symptoms, and it can worsen disease. Patient’s diseases are complex, and treatment which uses drugs is more complicated. This case suffer from SLE (Systemic Lupus Erythematosus).Therefore, using steroid to treat SLE, but steroid may have an great influence on blood glucose concentration on patient with diabetes mellitus. This case will research and discuss steroid how to affect control of blood glucose concentration and degree of blood glucose concentration. This was a clinical research which looked over and record simply blood glucose concentration after and before meal; using student's t-test analyze this clinical data. This study indicated that prednisolone had a great influence on blood glucose concentration on patient with diabetes mellitus statistically.