The goal of this study was to propose a career mentoring model for academic-industrial partnership. This model is a potential solution to the labor market inefficiency problem, in which college graduates found their skills sets obtained in school insufficient to meet the market demand. In addition, there existed disequilibrium in the quantity and quality job applicants of these graduates. Using Emmanuel College as a case study, the author attempted to answer the following questions through literature researches and the author’s own on-site practical experience: 1) why do we need career mentoring, 2) what are the benefits of career mentoring to industry, academy, and community, 3) what are the possible practices of career mentoring in academic-industrial partnership, 4) what are the potential challenges and solutions, and 5) conclusions. The results contribute to the research of human resource developments, and provide insights to educators and human resource managers.