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題名:Metabolic Effects of Paliperidone in a Patient with Schizophrenia
書刊名:Taiwanese Journal of Psychiatry
作者:許雅芬張震霖
作者(外文):Hsu, Ya-fenChang, Chen-lin
出版日期:2012
卷期:26:2
頁次:頁138-141+148
主題關鍵詞:第二代抗精神病藥物體重增高代謝症候群精神分裂症Second-generation antipsychotic drugPaliperidoneMetabolic syndromeSchizophrenia
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目的:使用第二代抗精神病劑治療精神分裂症具較佳療效。然而,它所產生運動障礙和代謝相關副作用是被廣泛擔憂的。較少報告提及第二代抗精神病劑paliperdone所產生的相關副作用,已知較常發生的藥物副作用包含錐體外症狀、頭痛、失眠、嗜睡和體重增加。本文提出一位精神分裂症病人以paliperidone治療後關於代謝副作用的臨床發現。病例報告:一位33歲男性病人於一年多前開始患有精神病症狀,此病人的精神病正性症狀,在paliperidone適當治療劑量和治療時程後,治療反應良好。但是,病人於治療一年期間體重由69.5公斤增至96.4公斤,且有高血脂和高尿酸血症之其他代謝副作用。病人主訴因代謝副作用而影響服藥順從性。結論:精神科醫師需要密切注意paliperidone治療後所產生的代謝副作用,並且應盡力預防或減少發生的可能性。
Objective: Second-generation antipsychotic (SGA) drugs have a favorable therapeutic beneficial profile in patients with schizophrenia. But, we have more concerns about their adverse events in metabolic effects, which are less studied in paliperidone, an SGA. Its reported side effects include extrapyramidal symptoms, headache, insomnia, and somnolence as well as weight gain. Here, we report a patient with schizophrenia who was treated with paliperidone and developed metabolic effects. Case Report: More than one year ago, 33 -year-old male patient with schizophrenia had psychotic symptoms and received paliperidone. He responded well to paliperidone and he was maintained with at adequate dosage and duration. His body weight was increased from 69.5 kg to 96.4 kg after one-year treatment. His other metabolic effects included dyslipidemia and hyperuricemia. But he had poor drug compliance after development of metabolic effects. Conclusion: Psychiatrists should be cautious about the possibility of having paliperidone-induced metabolic effects. Efforts on psychoeducation should be made to prevent or minimize the adverse effects.
期刊論文
1.Lieberman, J. A.、Stroup, T. S.、McEvoy, J. P.、Swartz, M. S.、Rosenheck, R. A.、Perkins, D. O.、Hsiao, J. K.(2005)。Effectiveness of antipsychotic drugs in patients with chronic schizophrenia。New England Journal of Medicine,353(12),1209-1223。  new window
2.Brown, S.、Inskip, H.、Barraclough, B.(2000)。Causes of the excess mortality of schizophrenia。British Journal of Psychiatry,177,212-217。  new window
3.Allison DB、Casey DE(2001)。Antipsychotic-induced weight gain: a review of the literature。J Clin Psychiatry,62 (suppl 7),22-31。  new window
4.Gianfrancesco, F.、White, R.、Wang, R. H.、Nasrallah, H. A.(2003)。Antipsychotic-induced type 2 diabetes: evidence from a large health plan database。J Clin Psychopharmacol,23,328-335。  new window
5.Casey DE(2005)。Metabolic issues and cardiovascular diseases in patients with psychiatric disorders。Am J Med.,118 (suppl2),15S-22S。  new window
6.Sertie AL、Suzuki AM、Sertie RA(2011)。Effects of antipsychotics with different weight gain liabilities on human in vitro model of adipose tissue differentiation and metabolism。Prog Neuropsychopharmacol Biol Psychiatry,35,1884-1890。  new window
7.Van BeijsterveldtLE、Geerts RJ、Leysen JE(1994)。Regional brain distribution of risperidone and its active metabolite 9-hydroxy-risperidonein the rat。Psychopharmacology,114,53-62。  new window
8.Chwieduk CM、Keating GM(2010)。Paliperidone extended release: a review of its use in the management of schizophrenia。Drugs,70,1295-1317。  new window
9.Hua J、Meyer JM、Sunder M、Jeste DV(2008)。Impact of atypical antipsychotics therapy on leptin, ghrelin and adiponectin.。Schizophr Res,100,70-85。  new window
10.Simon V、Van WR、De HM(2009)。Are weight gain and metabolic side effects of atypical antipsychotics dose dependent? literature review。J Clin Psychiatry,70,1041-1050。  new window
 
 
 
 
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