To enhance the development of high-tech industry, Hsinchu Science Park is constructed for integration of research and development and innovation of manufacturing in 1980. However, the overall sales of science parks in Taiwan were declined violently due to 2008 global financial crisis. The impact leads to dramatic reduction of CAPEX (capital expenditure) and technology development, while some companies had to lay off some employees and apply unpaid leave for cost reduction. In particular, most of talents with higher education are still in academia who need more opportunities to contribute their knowledge and technology for enhancing industry competitiveness. Therefore, administrations apply policy of science and technology through improvement in university-industry collaboration to foster the industry transformation and integrate the function of Science Park and university to sustain the research investments and improve the overall competitiveness in industry. This study aims to propose framework of university-industry collaboration through investigating the existing cooperation between university and industry and identifying the potential difficulties. To validate the proposed framework, an empirical study is applied by the program of university-industry collaboration of enhancing sustainable growth for NSC (National Science Council) Science Park. The results demonstrate the practical viability and provide a basis of policy of science and technology for innovation and university-industry collaboration in the future.