探討臺灣海洛因依賴個案感染人類免疫缺乏病毒之危險因子_

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題名：	探討臺灣海洛因依賴個案感染人類免疫缺乏病毒之危險因子
書刊名：	性學研究
作者：	高維聰
作者(外文)：	Kao, Wei-tsung
出版日期：	2013
卷期：	4:1
頁次：	頁17-40
主題關鍵詞：	人類免疫缺乏病毒；海洛因依賴；危險性行為；HIV；Heroin dependence；Sexual risk behavior
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(1) 博士論文(1) 專書(0) 專書論文(0) 排除自我引用:1 共同引用:12 點閱:20

目的：針對台灣海洛因依賴個案，探究危險性行為和人類免疫缺乏病毒（HIV）感染的相關因子。本研究採用病例對照研究設計（case-controlstudy），共收集314位海洛因依賴個案，區分有HIV感染之海洛因依賴個案為病例組26位，並以沒有HIV感染之海洛因依賴個案為對照組288位，所有個案都會接受血液檢查有無B型肝炎、C型肝炎、梅毒，且分別取得人口學相關資料、危險性行為及海洛因使用狀況資料，和進行研究相關問卷之施測，再做基因分析，包括MAOA基因多型性、DRD4基因多型性及RANTES基因多型性。結果：在海洛因依賴個案，經過t檢定，顯示得到HIV感染的個案，其受教育年限較少（t = 2.014, p = .045），經過卡方檢定，顯示得到HIV感染的個案，其較無疾病史（X^2 = 11.187, p = .001），顯示得到HIV感染的個案，其與同性別有發生過性行為的比例較高（X2 = 7.409, p = .006），顯示得到HIV感染的個案，有共用針頭的比例較高（X^2 = 8.971, p = .003），顯示得到HIV感染的個案，有共用海洛因之稀釋水的比例較高（X62 = 10.079, p = .001）。DRD4基因多型性為long form，較容易得到HIV感染（X^2 = 9.443, p = .002）。經過Logistic regression，發現DRD4 long form（odds ratio: 10.468; p = .007）與RANTES基因的Haplotype有GGC（odds ratio: 31.712; p = .046）這兩者是造成海洛因依賴個案得到HIV感染的重要因子。討論：DRD4 long form會使得靜脈注射藥癮者有較高的比例去共用針頭（X^2 = 4.937, p = .026），進而有較高的機會去被人類免疫缺乏病毒所感染。

以文找文

Objective: Explore the related factors of sexual risk behaviors and HIV infection in Taiwan Heroin dependence subjects. Method: The study was a casecontrol study. We had collected 314 Heroin dependence subjects. Case group was Heroin dependence subjects with HIV infection (26 cases) and control group was Heroin dependence subjects without HIV infection (288 cases). Whole subjects had received blood examinations including Hepatitis B, Hepatitis C and syphilis and had completed demographic data, sexual risk behavior and heroin use conditions data. They also completed the study related questionnaire. We made gene typing analysis including MAOA gene polymorphism, DRD4 gene polymorphism and RANTES gene polymorphism. Result: In Heroin dependence subjects, after t-test, subjects with HIV infection had lower education level (t = 2.014, p = .045). After chi-square test, subjects with HIV infection had fewer history of medical disease (X^2 = 11.187, p = .001). Subjects with HIV infections had more sexual experience with the same gender (X^2 = 7.409, p = .006). Subjects with HIV infections had more needle sharing experience (X2 = 8.971, p = .003). Subjects with HIV infections had more dilution water sharing experience (X^2 = 10.079, p = .001). Subjects with DRD4 long form had higher risk to have HIV infection (X^2 = 9.443, p = .002). After logistic regression, we found that DRD4 long form and RANTES gene GGC haplotype were important factors to Heroin dependence subjects with HIV infection. Discussion: DRD4 long form subjects had higher ratio to experience needle sharing (X^2 = .937, p = .026). So maybe due to the reason, subjects with DRD4 long form had higher risk to suffer HIV infection.

以文找文

期刊論文
1.	林豐材(2005)。試以生態學觀點談影響藥物濫用者的可能原因。網路社會學通訊期刊，48。延伸查詢
2.	Aguirre-Samudio, A. J.、Nicolini, H.(2005)。DRD4 polymorphism and the association with mental disorders。Revista de Investigación CUnica，57(1)，65-75。
3.	An, P.、Nelson, G. W.、Wang, L.、Donfield, S.、Goedert, J. J.、Phair, J.(2002)。Modulating influence on HIV/AIDS by interacting RANTES gene variants。Proceedings of the National Academy of Sciences of the United States of America，99，10002-10007。
4.	Ball, D.、Hill, L.、Freeman, B.、Eley, T. C.、Strelau, J.、Riemann, R.(1997)。The serotonin transporter gene and peer-rated neuroticism。Neuroreport，8，1301-1304。
5.	Beaver, K. M.、Wright, J. P.、Walsh, A.(2008)。A gene-based evolutionary explanation for the association between criminal involvement and number of sex partners。Biodemography and Social Biology，54，47-55。
6.	Berson, J. F.、Long, D.、Doranz, B. J.、Rucker, J.、Jirik, F. R.、Doms, R. W.(1996)。A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains。Journal of Virology，70，6288-6295。
7.	Bing, E. G.、Hays, R. D.、Jacobson, L. P.、Chen, B.、Gange, S. J.、Kass, N. E.(2000)。Health-related quality of life among people with HIV disease: Result from the multicenter AIDS cohort study。Quality of Life Research，9，55-63。
8.	Bleul, C. C.、Farzan, M.、Choe, H.、Parolin, C.、Clark-Lewis, I.、Sodroski, J.(1996)。The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry。Nature，382，829-833。
9.	Cases, O.、Seif, I.、Grimsby, J.、Gaspar, P.、Chen, K.、Pournin, S.(1995)。Aggressive behavior and altered amount of brain serotonin and norepinerphrine in mice lacking MAOA。Science，268，1763-1766。
10.	Chesney, M. A.、Barrett, D. C.、Stall, R.(1998)。Histories of substance use and risk behavior: Precursors to HIV seroconversion in homosexual men。American Journal of Public Health，88，113-116。
11.	Chien, C. C.、Lin, C. H.、Chang, Y. Y.、Lung, F. W.(2010)。Association of VNTR polymorphisms in the MAOA promoter and DRD4 exon 3 with heroin dependence in male Chinese addicts。World Journal of Biological Psychiatry，77，409-416。
12.	Cocchi, F.、DeVico, A. L.、Garzino-Demo, A.、Arya, S. K.、Gallo, R. C.、Lusso, P.(1995)。Identification of RANTES，MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells。Science，270，1811-1815。
13.	Darke, S.、Williamson, A.、Ross, J.、Teesson, M.、Lynskey, M.(2004)。Borderline personality disorder, antisocial personality disorder and risk-taking among heroin users: Findings from the Australian Treatment Outcome Study (ATOS)。Drug and Alcohol Dependence，74，77-83。
14.	Dragic, T.、Litwin, V.、Allaway, G. P.、Martin, S. R.、Huang, Y.、Nagashima, K. A.(1996)。HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5。Nature，381，667-673。
15.	Fellay, J.、Shianna, K. V.、Ge, D,、Colombo, S,、Ledergerber, B.、Weale, M.(2007)。A whole-genome association study of major determinants for host control of HIV-1。Science，317，944-947。
16.	Feng, Y.、Broder, C. C.、Kennedy, P. E.、Berger, E. A.(1996)。HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G proteincoupled receptor。Science，272，872-877。
17.	French, M. T.、Mauskopt, J. A.、Teague, J. L.、Roland, E. J.(1996)。Estimating the dollar value of health outcomes from drug-abuse interventions。Medical Care，34，890-910。
18.	Gelernter, J.、Kranzler, H.、Coccaro, E.、Siever, L.、New, A.、Mulgrew, C. L.(1997)。D4 dopamin-receptor (DRD4) alleles and novelty seeking in substancedependence, personality-disorder, and control subjects。American Journal of Human Genetics，61，1144-1152。
19.	Gerra, G.、Garofano, L.、Santoro, G.、Bosari, S.、Pellegrini, C.、Zaimovic, A.(2004)。Association between low-activity serotonin transporter genotype and heroin dependence: Behavioral and personality correlates。American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics，126B，37-42。
20.	Guo, G.、Tong, Y.、Xie, C. W.、Lange, L. A.(2007)。Dopamine transporter, gender, and number of sexual partners among young adults。Dopamine Transporter，Gender, and Number of Sexual Partners among Young Adults，15，279-287。
21.	Hagan, H.、Thiede, H.、Weiss, N. S.、Hopkins, S. G.、Duchin, J. S.、Alexander, E. R.(2001)。Sharing of drug preparation equipment as a risk factor for hepatitis C.。American Journal of Public Health，91，42-46。
22.	Hall, H. I.、Song, R.、Rhodes, P.、Prejean, J.、An, Q.、Lee, L. M.(2008)。Estimation of HIV incidence in the United States。Journal of American Medical Association，300，520-529。
23.	Hartgers, C.、Van den Hoek, J. A.、Coutinho, R. A.、Van der Pligt, J.(1992)。Psychopathology, stress and HIV-risk injecting behavior among drug users。British Journal of Addiction，87，857-865。
24.	Huang, Y. Y.、Cate, S. P.、Battistuzzi, C.、Oquendo, M. A.、Brent, D.、Mann, J. J.(2004)。An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulse traits and early abuse experiences。Neuropsychopharmacology，29，1498-1505。
25.	Ickovics, J. R.、Hamburger, M. E.、Vlahov, D.、Schoenbaum, E. E.、Schuman, P.、Boland, R. J.(2001)。Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women。Journal of the American Medical Association，285，1466-1474。
26.	Kaur, G.、Mehra, N.(2009)。Genetic determinants of HIV-1 infection and progression to AIDS: Susceptibility to HIV infection。Tissue Antigens，73，289-301。
27.	Kendler, K. S.、Jacobson, K. C.、Prescott, C. A.、Neale, M. C.(2003)。Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins。American Journal of Psychiatry，160，687-695。
28.	Koester, S.、Glanz, J.、Baron, A.(2005)。Drug sharing among heroin networks: Implications for HIV and hepatitis B and C prevention。AIDS and Behavior，9，27-39。
29.	Kokkevi, A.、Stefanis, N.、Anastasopoulou, E.、Kostogianni, C.(1998)。Personality disorders in drug abusers: Prevalence and their association with AXIS I disorders as predictors of treatment retention。Addictive Behaviors，23，841-853。
30.	Koob, G. R、Nestler, E. J.(1997)。The neurobiology of drug addiction。Journal of Neuropsychiatry and Clinical Neuroscience，9，482-497。
31.	Kozlov, A. A.、Rokhlina, M. L.(2000)。“Addictive” personality。Zhurnal nevropatologii ipsikhiatrii imeni S.S. Korsakova，100(7)，23-27。
32.	Lee, T. S.(2012)。Penile bead implantation in relation to HIV infection in male heroin users in Taiwan。Journal of AIDS & Clinical Research，3(S1)，1-6。
33.	Lee, Tony Szu-Hsien、Shen, H. C.、Wu, W. H.、Huang, C. W.、Yen, M. Y.、Wang, B. E.(2011)。Clinical characteristics and risk behavior as a function of HIV status among heroin users enrolled in methadone treatment in northern Taiwan。Substance Abuse Treatment, Prevention & Policy，6。
34.	Lesch, K. P.、Bengel, D.、Heils, A.、Sabol, S. Z.、Greenberg, B. D.、Petri, S.(1996)。Associations of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region。Science，274，1527-1531。
35.	Levran, O.、Londono, D.、O’Hara, K.、Nielsen, D. A.,、Peles, E.、Rotrosen, J.(2008)。Genetic susceptibility to heroin addiction: A candidate gene association study。Genes, Brain, and Behavior，7，720-729。
36.	Li, T.、Xu, K.、Deng, H.、Cai, G.、Liu, J.、Liu, X.(1997)。Association analysis of the dopamine D4 gene exon III VNTR and heroin abuse in Chinese subjects。Molecular Psychiatry，2，413-416。
37.	Li, T.、Zhu, Z. H.、Liu, X.、Hu, X.、Zhao, J.、Sham, P. C.(2000)。Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects。American Journal of Medical Genetics，96，616-621。
38.	Liu, H.、Chao, D.、Nakayama, E. E.、Taguchi, H.、Goto, M.、Xin, X.(1999)。Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression。Proceedings of the National Academy of Sciences，96，4581-4585。
39.	Liu, H.、Hwangbo, Y.、Holte, S.、Lee, J.、Wang, C.、Kaupp, N.(2004)。Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1。Journal of Infectious Diseases，190，1055-1058。
40.	Liu, X. L.、Wang, F. S.、Jin, L.、Liu, M. X.、Xu, D. Z.(2003)。Preliminary study on the association of chemokine RANTES gene polymorphisms with HIV-1 infection in Chinese Han population。Zhonghua Liu Xing Bing Xue Za Zhi，24，971-975。
41.	Lodhi, P. H.、Thakur, S.(1993)。Personality of drug addicts: Eysenckian analysis。Personality and Individual Differences，15，121-128。
42.	Mahanta, J.、Medhi, G. K.、Paranjape, R. S.、Roy, N.、Kohli, A.、Akoijam, B. S.(2008)。Injecting and sexual risk behaviours, sexually transmitted infections and HIV prevalence in injecting drug users in three states in India。AIDS，22，59-68。
43.	Mahungu, T. W.、Johnson, M. A.、Owen, A.、Back, D. J.(2009)。The impact of pharmacogenetics on HIV therapy。International Journal of STD & AIDS，20，145-151。
44.	Matt, C.、Roger, M.(2001)。Genetic determinants of pediatric HIV-1 infection: Vertical transmission and disease progression among children。Molecular Medicine，7，583-589。
45.	McDermott, D. H.、Beecroft, M. J.、Kleeberger, C. A.、Al-Sharif, F. M.、Oilier, W. E.、Zimmerman, P. A.(2000)。Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study。AIDS，14，2671-2678。
46.	Meyer, R. E.(1996)。The disease called addiction: Emerging evidence in a 200-year debate。Lancet，347，162-166。
47.	Mills, K.,、Teesson, M.、Darke, S.、Ross, J. E.、Lynskey, M. T.(2004)。Young people with heroin dependence: Findings from the Australian Treatment Outcome Study (ATOS)。Journal of Substance Abuse Treatment，27，67-73。
48.	Oberlin, E.、Amara, A.、Bachelerie, F.、Bessia, C.、Virelizier, J. L.、Arenzana-Seisdedos, F.(1996)。The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1。Nature，382，833-835。
49.	Palepu, A.、Strathdee, S. A.、Hogg, R. S.、Anis, A. H.、Rae, S.、Comelisse, P. G.(1999)。The social determinants of emergency department and hospital use by injection drug users in Canada。Journal of Urban Health，76，409-418。
50.	Piette, J. D.、Fleishman, J. A.、Stein, M. D.、Mor, V.、Mayer, K.(1993)。Perceived needs and unmet needs for formal services among people with HIV disease。Journal of Community Health，18，11-23。
51.	Robin, T. W.、Everitt, B. J.(1999)。Drug addiction: Bad habits add up。Nature，398，567-570。
52.	Siegel, I.(1996)。Possibilities and limits of drug substitution treatment in ambulatory practice。Zeitschrift fur Arztliche FortbUdung，90，307-313。
53.	Sherbourne, C. D.、Hays, R. D.、Fleishman, J. A.、Vitiello, B.、Magruder, K. M.、Bing, E. G.(2000)。Impact of psychiatric conditions on health-related quality of life in persons with HIV infection。American Journal of Psychiatry，157，248-254。
54.	Strathdee, S. A.、Galai, N.、Safaiean, M.、Celentano, D. D.、Vlahov, D.、Johnson, L.(2001)。Sex differences in risk factors for HIV seroconversion among injection drug users: A 10-year perspective。Archives of Internal Medicine，161，1281-1288。
55.	Tsuang, M. T.、Lyons, M. J.、Eisen, S. A.、Goldberg, J.、True, W.、Lin, N.(1996)。Genetic influences on DSM-III-R drug abuse and dependence: A study of 3,372 twin pairs。American Journal of Medical Genetics，7，473-477。
56.	Tsuang, M. T.、Lyons, M. J.、Meyer, J. M.、Doyle, T.、Eisen, S. A.、Goldberg, J.(1998)。Co-occurrence of abuse of different drugs in men: The role of drugspecific and shared vulnerabilities。Archives of General Psychiatry，55，967-972。
57.	Vanyukov, M. M.、Maher, B. S.、Devlin, B.、Kirillova, G. R.、Kirisci, L.、Yu, L. M.(2007)。The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: Gene-environment interaction。Psychiatric Genetics，17，323-332。
58.	Walderhaug, E.、Lunde, H.、Nordvik, J. E.、Landrǿ, N. I.、Refsum, H.、Magnusson, A.(2002)。Lowering of serotonin by rapid tryptophan depletion increases impulsiveness in normal individuals。Psychopharmacology，164，385-391。
59.	Webber, M. P.、Schoenbaum, E. E.、Gourevitch, M. N.、Buono, D.、Klein, R. S.(1999)。A prospective study of HIV disease progression in female and male drug users。AIDS，13，257-262。
60.	Williams, J. B.、Rabkin, J. G.、Remien, R. H.、Gorman, J. M.、Ehrhardt, A. A.(1991)。Multidisciplinary baseline assessment of homosexual men with and without immunodeficiency virus infection. II. Standardized clinical assessment of current and lifetime psychopathology。Archives of General Psychiatry，48，124-130。
61.	Yang, X.、Latkin, C.、Celentano, D.、Luo, H.(2006)。Prevalence and correlates of HIV risk behaviors among drug users in China。AIDS and Behavior，2，71-81。
62.	Zhao, X. Y.、Lee, S. S.、Wong, K. H.、Chan, K. C.、Ma, S.、Yam, W. C.(2004)。Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese。European Journal of Immunogenetics，31，179-183。
63.	Zhou, Y. H.、Yao, Z. H.、Liu, F. L.、Li, H.、Jiang, L.、Zhu, J. W.(2012)。High prevalence of HIV, HCV, HBV and co-infection and associated risk factors among injecting drug users in Yunnan Province, China。PloS One，7(8)，e42937。
64.	Lu, L.、Chen, C. S.(1996)。Correlates of coping behaviours: Internal and external resources。Counselling Psychology Quarterly，9，297-307。
65.	Lu, L.(1999)。Personal or Environmental Causes of Happiness: A Longitudinal Analysis。The Journal of Social Psychology，139(1)，79-90。
66.	蘇東平(19800400)。臺灣青少年之藥物濫用。臨床醫學，5(4)，299-305。延伸查詢
67.	蘇東平(19801100)。臺灣青少年之藥物濫用。臨床醫學，6(5)，412-421。延伸查詢
68.	Brown, G. R.、Rundell, J. R.、McManis, S. E.、Kendle, S. N.、Zachary, R.、Temshok, L.(1992)。Prevalence of psychiatric disorders in early stages of HIV infection。Psychosomatic Medicine，54，588-601。
69.	Lung, F. W.、Lin, T. J.、Lu, Y. C.、Shu, B. C.(2004)。Personal Characteristics of Adolescent Prostitutes and Rearing Attitudes of their Parents: a Structural Equation Model。Psychiatry Research，125，285-291。
70.	Brunner, H. G.、Nelen, M.、Breakefield, X. O.、Ropers, H. H.、van Oost, B. A.(1993)。Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A。Science，262，578-580。

研究報告
1.	衛生署疾病管制局(2012)。愛滋病統計資料。延伸查詢

圖書
1.	高金桂(1984)。毒品犯濫用藥物與犯罪之研究。台北市：文景。延伸查詢
2.	Goldberg, D. P.(1972)。The detection of psychiatric illness by questionnaire: A technique for the identification and assessment of non-psychotic psychiatric illness。Oxford University Press。
3.	Goldberg, D. P.、Williams, P.(1988)。A User's guide to the general health questionnaire。NFER-Nelson。
4.	World Health Organization(2003)。HIV/AIDS in Asia and the Pacific region 2003。Geneva, Switzerland：World Health Organization。

其他
1.	United Nations Programme on HIV/AIDS(2007)。AIDS epidemic update: December 2007，Geneva, Switzerland：United Nations Programme on HIV/AIDS (UNAIDS)：World Health Organization (WHO)。

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