Objectives: The operating room is the costliest and most complex department in the hospital as well as being high specialized and responsible for substantial revenue. The purpose of this study was to increase the utilization rate of surgical instrument packages, and to decrease the number of packages that passed their expiration date in order to decrease re-sterilizing of those packages in terms of manpower and cost.Methods: This study explored factors influencing redoing of surgical instrument packages based on the records of the surgical and obstetric and gynecological units of the case hospital. These equipment use records were analyzed in terms of percentages, means, and maximums.Results: Packages with a low utilization rate were then either reduced in number or taken off the shelf; 20 categories with 1,445 packages were reduced in number to save redoing at a cost of NT 4,485,280 per year; 19 categories with 120 packages were taken off the shelf to save redoing at a cost of NT 372,480 per year; some of the off the shelf packages were transferred to the supply unit as spares to avoid a new purchase cost of NT 64,362,100.Conclusions: There was a significant correlation between redo rate and cost. Reducing the quantity of some instrument packages, taking some off the shelves, changing the way some were packaged, extending the expiration date, and regular monitoring were implemented to enhance management. In order to lower operating costs and maintain the same quality of service, managers should review the operation of surgical instrument packaging on a regular basis to decrease the redo rate and reduce costs.