This study investigates the effects of macroeconomic factors, such as the rate of economic growth, the annual growth rate in per capita GNP, the annual growth rate of population, the annual growth rate of CPI, the change rate of exchange rate, and the annual growth rate of unemployment rate, on the defense expenditure by taking Taiwan and South Korea as examples. The multi-linear regression model is applied in this study. The empirical results show that both the annual growth rate in per capita GNP and the annual growth rate of CPI present positive effects on the defense expenditure, while both the rate of economic growth and the change rate of exchange rate appear negative effects on the defense expenditure in Taiwan. The reasons for the results could be that Taiwan’s defense expenditure is limited by the budget crowd-out effects from government policies and social welfare. For the part of South Korea, the change rate of exchange rate presents positive effects on the defense expenditure, while both the annual growth rate in per capita GNP and the annual growth rate of unemployment rate appear negative effects on the defense expenditure.