The enforcement of antitrust law against foreign companies for conduct outside the territory, which affects internal commerce, has for many years caused considerable international tension. The jurisdiction of antitrust law extends to restraints of foreign concerns whether or not the objectionable conduct occurred in the territory, if the requisite “effect” on internal commerce is present. This article will generalize the territorial principle and the effect doctrine in the extraterritorial application of antitrust law in U.S. and EU judicial determinations and also conclude a reasonable boundary line of the extraterritorial application of antitrust law.