對德勒茲而言，差異是「哲學的真正開始」，但每一差異同時卻又總是「已經重複」，哲學的源起於是處於一種獨特的張力之中：已經重複的差異標誌一種真正開始，但哲學本身則充實於此「真正開始」的不斷開始，換言之，在真正開始與已經重複之間哲學誕生，哲學就是哲學的系列開始本身。這是何以對差異與重複的構思對德勒茲具有無比的重要性，德勒茲的全部哲學似乎圍繞這個獨特的起源命題，由此衍生他對於哲學史與美學經驗（文學、繪畫、電影、音樂與戲劇）的問題性。

The present paper seeks to discuss how Deleuze conceptualizes the difference as the veritable beginning of philosophy, and on the other hand, how difference serves as an ”already repetition.” The philosophical genesis remains situated and saturated in a permanent and singular intensity: difference of being already repetition implicates a veritable beginning, but the philosophy ends in the repetition of the beginning. Intertwined between the veritable beginning and already repetition, philosophy is thus brought to its emergence, and then placed in its series of (re)commencement. This explains why the concept of difference and repetition plays a pivotal role in examining the thought of Deleuze. As such, the paper attempts to demonstrate how Deleuze's philosophy is dedicated to the stake of genesis, the stake stemming from the profusion of genealogical inheritance, such as the philosophical thread sparked from Spinoza to Foucault through Leibniz. Also, the genealogical inheritance of genesis opens Deleuze's thought onto the problematic of philosophy and aesthetics such as the genres of literature, painting and cinema.