The highest rate of medical personnel accident is needlestick injury, also the largest sources of psychological stress. How to improve needlestick injury of risk is the most important issue for the medical personnel safety and health promotion. For this project, apply the risk identifi cation, analysis, evaluation, improvement, feedback management model, To Implementation of risk management, Application creativity methods and inherently safer design strategies to improve risk. The aforementioned management model, Thesis and the Chinese version of Exposure Prevention Information Network (EPINet) informed to identify needlestick injury risk projects. Failure Modes and Effects Analysis (FMEA), combined with innovative horizontal Cause-Consequence Analysis (CCA) to identify Major risk, combination of creative methods and inherently safer design strategies, Invention needle sleeve and proposed anti-needlestick gloves plan to significantly reduce the risk, submit the balance test, the site education with qualified granted in Chapter, personal protective gear check program Etc. Let managers according to considerations of cost, schedule to select the applicable program to improve the residual risk, should be promoted and applied to similar risks.