With the rapid growth of technological development, the numbers of Smartphone users had increased year-over-year recently, and it also changes modern lifestyle. As the traits of smartphone is instant, portable and convenience, it brings lots of benefits to human's life, but also has negative impacts such as excessive dependence on smartphone. It can be called ＂Phone Dependency Syndrome＂ or ＂Mobile Phone Addiction＂. It could be realized that the influence of smartphone should not be underestimated. Issues that related to the ＂Mobile Phone Addiction＂ were gathered by social attention. The main purpose of this study is to investigate the positive and negative influence on personal background, usage behaviors, interpersonal relationship, family relationships, Psychological and Physiological. The research is based on Taiwanese resident, using the questionnaire survey and SPSS statistical software to analyze data. The empirical results are ＂Positive Interpersonal Relationships＂ to the users' ＂age,＂ ＂daily usage,＂ ＂weekly usage,＂ and ＂life time＂ all have significant differences, and ＂Negative Interpersonal Relationship＂ also have significant differences in users' ＂ages＂ and ＂education level.＂ And ＂Positive Psychological＂ for users' ＂age＂, ＂daily usage,＂ ＂weekly usage,＂ and ＂life time＂ have significant differences, and ＂Negative Psychological＂ has significant difference to user's ＂education level,＂ ＂daily usage＂ and ＂life time.＂ According to the research, the result might be helpful as reference for counseling psychologist, practitioners in fields like family or school education.