Driving under the influence (DUI) poses a major threat to roadway traffic and safety. It not only endangers the safety of drivers, but also puts innocent road users’ lives at risk. It will seriously endanger social stability and destroy the welfare of involved families. According to the National Police Agency (NPA), drunk driving has been one of the leading causes for fatality traffic accidents in Taiwan in the past 10 years. This study reviewed and compared penalties imposed on drunk driving among different countries, and utilized the DUI statistics released by the NPA to analyze behaviors and characteristics of drunk driving. Moreover, a thorough review of the DUI prevention measures in Taiwan was made and recommendations for future enforcement was provided as follows: Police departments should continue their strict DUI enforcement and deploy police forces accordingly after taking into account such factors as different road conditions, vehicle usage habits of drivers and the characteristics of DUI. In the meantime, the police departments should conduct anti-DUI awareness campaigns and impose severe punishment on reoffending drunk drivers. Furthermore, the DUI laws shall be revised to charge stricter penalties on reoffending drunk drivers and those drivers with high breath alcohol content. City and county government administrators are also advised to pay more attention on DUI enforcement in their jurisdictions.