Most medical institutions comply with Ministry of Health and Welfare regulations to label the basic 16 items of medicine information. However, the labels tend to be limited in length due to the size of the label, and the contents are usually written in professional and scientific manner, inhibiting the patients and their family from comprehension of the medicines they take. The systems proposed in this paper can enhance the understanding of the medication by the patients and their family, thus reduce information asymmetry between medical institutions and the patients. This research proposes a medicine query system for mobile devices that integrates multimedia technologies. And the QR Code Drug query systems are developed with Incremental Prototype Method. By scanning the Quick Response Code (QR Code) with mobile devices, the patients can access the 3D models and multimedia introduction of the medication, thus obtain specific and in-depth information. So this research can make four contributions: (1) enhance general public's understanding of medicines, (2) Impress medication receiver with interactive query and multimedia content, (3) Complement printed prescription and instructions on medicine bags, and (4) promote medication safety by providing plane and easy to understand content for elder citizens and kids.