The purpose of this study was to construct and examine the structural equation model between the variables of leisure coping strategies, leisure sport participant and life quality in college student. Cluster sampling was to use and to select 7 classes in Chienkuo Technology University. Overall, 400 sets of survey were sent and 322 valid responses were received. Data was analyzed by exploratory factor analysis (EFA) and structural equation modeling (SEM). The results indicated the following: (1) leisure coping strategies has a positive and significant effect on life quality; (2) leisure coping strategies has a positive and significant effect on leisure sport participation; (3) leisure sport participation has a positive and significant effect on life quality. Managerial implications are discussed and future research directions are proposed in this study as well.