Marginal abatement cost analysis has been widely used in exploring the potential measures for energy saving and emission reduction. It provides governments with solid reference in making future energy development strategy. Taiwan 2050 Calculator is an energy simulation tool that can calculate several aspects of impacts to Taiwan, such as energy security, energy price and environmental impacts, based on the given future scenario configurations on 130 energy technology or measures. This study is to construct the marginal abatement cost model and analyze the result of different scenario configurations based on the existing Taiwan 2050 Calculator framework. In this study, the Base Scenario is defined as “do nothing” scenario, the calculations of emission reduction and marginal abatement cost of all technology or measures are related to the outcome of Base Scenario. Two future development scenarios are defined and analyzed: Ambitious and Very Ambitious scenarios. These two scenarios had well defined and configured in the Taiwan 2050 Calculator already, and this study constructed essential calculation to generate emission reduction and marginal abatement cost figures of technology or measures. This result shows, in 2030, Ambitious scenarios will have the potential to reduce 150 million tons of carbon dioxide emission in Taiwan, while Very Ambitious scenarios will bring about 200 million tons of reduction. This research investigates the reduction potential and cost of a wide of energy technology or measures. The result can be a solid reference for the government to realize appropriate energy mix in the future.