隨著科技的進步，造成人們精神疾病的增加。憂鬱症已經成為耗費個人及社會成本很高的文明病。過去治療憂鬱最常使用的方式就是藥物與心理治療，但缺點在其產生的副作用與昂貴的成本。近來，許多研究顯示運動為一種可行且具經濟效益的治療方式。本研究主要是以運動訓練與血清素濃度的形式、應用及其相關的理論，進而以實證性文獻探究對憂鬱症表現之影響。方法是透過文獻蒐集的方式，將所得資料加以歸納、分析與整合。並從中探討模式與歷程、理論之相關聯性及其對抗與減輕對憂鬱症表現的影響。期望藉此能夠做為運動科學治療的參考。研究結果可知：人體血清素濃度與憂鬱症成因關係密不可分，透過適度運動有助於活化血清素系統達到穩定血清素濃度的效果，進而減輕憂鬱症狀並改善憂鬱情緒。

As the technology develop, mental illness prevalence are also increased. Depression disorder has turned out to be civilization disease which consumes high personal and social costs. In the past, treatments commonly used were medication and psychotherapy. However, those generated side effects and needed high cost. Currently, some research reported that exercise can become a reliable and cheaper treatment method. This research mainly observed the correlation between exercise and serotonin and discussed their impact on depressive symptom using empirical literature. The method used was through the literature study by collecting, summarizing, analyzing, and integrating obtained data. Pattern exploration in history and correlated theories were used to observe the effect of exercise on preventing or reducing depressive symptoms. It is expected that the result can be used as reference on sport science treatment. Results revealed that human serotonin concentration correlated closely to depressive disorder and moderate exercise can help to activate the serotonin system to stabilize levels of serotonin, which in turn can reduce depressive symptom and improve mood condition.