The trend of globalization has changed the world's social and economic development in the 1980s. Continually, the Four Asian Tigers (or called as Asian Dragons) has become a significant regional economic development momentum which driven with the significance of regional integration in the Asia-Pacific since the 1990s. On the other hand, the “Return” and “Liberalization” of the gambling industry led the rapid growth of Macau economy in recent years. Most of the Asian countries had committed for marketing segmentation and welfares from the regional integration while the regional economic integrations are processing vitally in the Asia-Pacific, such as APT, AFTA, and TPP etc. Several voices argued that the marginalization by the new trend of regional economic integration is affecting the future of Macau’s economic growth. Meanwhile, what is the roles-playing for Macau undergoing the new wave of economic regionalization in the region? Moreover, another question raised that how to explore a new positioning which is suitable for the economic development of Macau? Above questions are perspective, and those worth to be explored deliberatively by all circles in Macau.