The development of mobile devices and wireless network technologies progress rapidly and become popularity. It increases the feasibility of the emergency disease reporting by using smart phone and tablet personal computer. Taking the limit of environment into account, the cross-platform and offline services are in need. Monitoring and prevention of disease usually have timeliness requirements. In this project, we cooperated with Center for Disease Control, Taiwan to implement a disease reporting system by using the advantages of intelligent mobile devices. More than that, an application could record those accidents and diseases for mass gatherings have been included as well. The architecture of this system is divided into server-side and client mobile devices applications. There are three modules including (1) Offline Data Records Module: for the bad internet conditions, offline module provides downloading the data and program to a mobile device. It lead users can do the normal functions in the no internet area, and can upload the data to server after the connection is recovered. (2) Account Management Module: control the users' access right for each group of users. (3) Data Management Module: updates and synchronizes the database in the server and the client sites. The system was implemented in software tools including Hyper-Text Markup Language 5 (HTML5), JavaScript Language, jQuery mobile, Cascading Style Sheets (CSS) development system, Web Structured Query Language (SQL) database and offline application system. The system now is already passed many tests. For the real evaluation, the application was used for the injured student's record in the sports of university celebration. The system is still updating and renewing for use abroad in few years. We believed that the system will be helpful for diseases and accident report in the future.