資料載入處理中...
臺灣人文及社會科學引文索引資料庫系統
:::
網站導覽
國圖首頁
聯絡我們
操作說明
English
行動版
(3.129.22.164)
登入
字型:
**字體大小變更功能,需開啟瀏覽器的JAVASCRIPT,如您的瀏覽器不支援,
IE6請利用鍵盤按住ALT鍵 + V → X → (G)最大(L)較大(M)中(S)較小(A)小,來選擇適合您的文字大小,
如為IE7以上、Firefoxy或Chrome瀏覽器則可利用鍵盤 Ctrl + (+)放大 (-)縮小來改變字型大小。
來源文獻查詢
引文查詢
瀏覽查詢
作者權威檔
引用/點閱統計
我的研究室
資料庫說明
相關網站
來源文獻查詢
/
簡易查詢
/
查詢結果列表
/
詳目列表
:::
詳目顯示
第 1 筆 / 總合 1 筆
/1
頁
來源文獻資料
摘要
外文摘要
引文資料
題名:
上呼吸道模型微粒沉積特性研究:CT掃瞄模型與真人比對測試
書刊名:
勞動及職業安全衛生研究季刊
作者:
黃盛修
/
鄭見福
/
陳春萬
/
陳志傑
作者(外文):
Huang, Sheng-hsiu
/
Cheng, Chien-fu
/
Chen, Chun-wan
/
Chen, Chih-chieh
出版日期:
2015
卷期:
23:4
頁次:
頁363-375
主題關鍵詞:
微粒沉積
;
上呼吸道模型
;
電腦斷層掃描
;
Aerosol deposition
;
Upper airway cast
;
Computed tomography
原始連結:
連回原系統網址
相關次數:
被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0)
排除自我引用:0
共同引用:0
點閱:21
了解微粒在呼吸道的沉積特性,不但有助於粒狀汙染物的暴露評估,對於呼吸道疾病的藥 物輸送效率設計也能提供有用的建議。上呼吸道模型是研究呼吸道微粒沉積效率常見的方法, 已被沿用多年,但是過去的研究證明上呼吸道模型能有效代表真人實際沉積情形的方式,均為 收集文獻中人體實驗的資料來互相比較,至今仍未有研究嘗試比較同一受試者之上呼吸道模型 與真人測試資料的差異。為了探討上呼吸道模型的研究結果是否能有效代表真人的沉積情形, 本研究找一名非吸菸的健康成年男性當受試者,以其電腦斷層掃描 (computed tomography, CT) 影像為基礎製作上呼吸道模型。CT影像諮詢專業的耳鼻喉科醫 師協助判斷,避免混淆鼻道與 鼻竇的範圍。使用超音波霧化器與定量輸出霧化器產生微米級與次微米級微粒。微粒經過射源 (25 mCi Am241),使整個氣膠團帶電呈波茲曼平衡。使用氣動微粒分徑器(偵測粒徑範圍大於 0.7μm)和微粒電移動度掃瞄分徑器(偵測粒徑範圍小於 0.7μm)來量測上下游的微粒分佈與 濃度。真人量測鼻入口出沉積率時,次微米級微粒改用快速微粒電移動度粒徑分析儀量測。實 驗結果發現真人測試時,暫停呼吸的方式會顯著影響沉積率。上呼吸道模型的鼻入口出壓降與 沉積率均與真人測試的結果很相似。隨著抽氣流率增加,微米級微粒的沉積率也會增加,代表 微米級微粒的沉積機制是慣性衝擊。
以文找文
Aerosol deposition efficiency in airway is useful for particle matter exposure assessment and inhaled drug delivery industry. Upper airway cast is a conventional method for airway deposition studies. The object of this study is to characterize the artificial cast deposition efficiency by comparing with in vivo measurements of the same subject. This study recruited a Taiwanese healthy male adult volunteer to take computed tomography (CT) scan, and the dimensions of the cast were referred to the CT scan images. For aerosol deposition test, a TSI constant output and an ultrasonic atomizing nozzle were used to generate submicro-meter-sized and micrometer-sized aerosols, respectively. The aerosol output was then neutralized by a radioactive source, 25 mCi Am241, to the Boltzmann charge equilibrium. A Scanning Mobility Particle Sizer (for particle < 0.7 μm) and an Aerosol Particle Sizer (for particles > 0.7 μm) were used to measure the aerosol concentration and size distribution upstream and downstream of the casts. A Fast Mobility Paticle Sizer was used to measure the aerosol deposition in the nasal cavity while the subjects held breaths. The breath holding maneuvers of the subject would affect aerosol depositions significantly. The nasal-in-mouth-out aerosol deposition through the cast correlated reasonably well with that through the same human subject. However, the CT scan image takes a well trained ENT doctor to correctly interpret. Otherwise, some of the sinus cavity might be treated as the air pathways. For micrometer-sized aerosols, the deposition efficiency in the casts increased with increasing sampling flow, indicating that inertial impaction was the dominating mechanism.
以文找文
期刊論文
1.
Cheng, Y. S.、Yamada, Y.、Yeh, H. C.、Swift, D. L.(1988)。Diffusional deposition of ultrafine aerosols in a human nasal cast。Journal of Aerosol Science,19,741-751。
2.
Cheng, Y. S.、Zhou, Y.、Chen, B. T.(1999)。Particle Deposition in a Cast of Human Oral Airways。Aerosol Science and Technology,31,286-300。
3.
Golshahi, L.、Finlay, W. H.、Olfert, J. S.、Thompson, R. B.、Noga, M. L.(2010)。Deposition of Inhaled Ultrafine Aerosols in Replicas of Nasal Airways of Infants。Aerosol Science and Technology,44,741-752。
4.
Cheng, Y. S.、Yeh, H. C.、Guilmette, R. A.、Simpson, S. Q.、Cheng, K. H.、Swift, D. L.(1996)。Nasal Deposition of Ultrafine Particles in Human Volunteers and Its Relationship to Airway Geometry。Aerosol Science and Technology,25,274-291。
5.
Swift, D. L.(1991)。Inspiratory Inertial Deposition of Aerosols in Human Nasal Airway Replicate Casts - Implication For the Proposed NCRP Lung Model。Radiation Protection Dosimetry,38,29-34。
6.
Kelly, J. T.、Asgharian, B.、Kimbell, J. S.、Wong, B. A.(2004)。Particle deposition in human nasal airway replicas manufactured by different methods。Part I: Inertial regime particles. Aerosol Science and Technology,38,1063-1071。
7.
Cheng, Y. S.、Hansen, G. K.、Su, Y. F.、Yeh, H. C.、Morgan, K. T.(1990)。Deposition of ultrafine aerosols in rat nasal molds。Toxicology and Applied Pharmacology,106,222-233。
8.
Johnson, G. R.、Ristovski, Z.、Morawska, L.(2004)。Method for measuring the hygroscopic behaviour of lower volatility fractions in an internally mixed aerosol。Journal of Aerosol Science,35,443-455。
9.
Cheng, Y. S.、Yamada, Y.、Yeh, H. C.、Swift, D. L.(1990)。Deposition of Ultrafine Aerosols in a Human Oral Cast。Aerosol Science and Technology,12,1075-1081。
10.
Cheng, K. H.、Cheng, Y. S.、Yeh, H. C.、Swift, D. L.(1995)。Deposition of Ultrafine Aerosols in the Head Airways During Natural Breathing and During Simulated Breath Holding Using Replicate Human Upper Airway Casts。Aerosol Science and Technology,23,465-474。
11.
Swift, D. L.、Montassier, N.、Hopke, P. K.、Karpen-Hayes, K.、Cheng, Y. S.、Yin, Fong(1992)。Inspiratory deposition of ultrafine particles in human nasal replicate cast。Journal of Aerosol Science,23,65-72。
12.
Zhou, Y.、Cheng, Y. S.(2005)。Particle Deposition in a Cast of Human Tracheobronchial Airways。Aerosol Science and Technology,39,492-500。
13.
Zhou, Y.、Sun, J.、Cheng, Y. S.(2011)。Comparison of Deposition in the USP and Physical Mouth Throat Models with Solid and Liquid Particles。Journal of Aerosol Medicine and Pulmonary Drug Deliv,24,277-284。
14.
Storey-Bishoff, J.、Noga, M.、Finlay, W. H.(2008)。Deposition of micrometer-sized aerosol particles in infant nasal airway replicas。Journal of Aerosol Science,39,1055-1065。
15.
Eshbaugh, J. P.、Gardner, P. D.、Richardson, A. W.、Hofacre, K. C.(2009)。N95 and P100 Respirator Filter Efficiency Under High Constant and Cyclic Flow。Journal of Occupational and Environmental Hygiene,6,52-61。
16.
Cheng, Y. S.、Smith, S. M.、Yeh, H. C.、Kim, D. B.、Cheng, K. H.、Swift, D. L.(1995)。Deposition of Ultrafine Aerosols and Thoron Progeny in Replicas of Nasal Airways of Young Children。Aerosol Science and Technology,23,541-552。
17.
Cheng, K. H.、Cheng, Y. S.、Yeh, H. C.、Guilmette, R. A.、Simpson, S. Q.、Yang, Y. H.、Swift, D. L.(1996)。In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways。Journal of Aerosol Science,27,785-801。
18.
Kim, C. S.、Iglesias, A. J.(1989)。Deposition of Inhaled Particles in Bifurcating Airway Models: I. Inspiratory Deposition。Journal of Aerosol Medicine,2,1-14。
19.
Kim, C. S.、Iglesias, A. J.、Garcia, L.(1989)。Deposition of Inhaled Particles in Bifurcating Airway Models: II. Expiratory Deposition。Journal of Aerosol Medicine,2,15-27。
20.
Kesavanathan, J.、Swift, D. L.(1998)。Human Nasal Passage Particle Deposition: The Effect of Particle Size, Flow Rate, and Anatomical Factors。Aerosol Science and Technology,28,457-463。
21.
Kelly, J. T.、Asgharian, B.、Kimbell, J. S.、Wong, B. A.(2004)。Particle deposition in human nasal airway replicas manufactured by different methods. Part II: Ultrafine particles。Aerosol Science and Technology,38,1072-1079。
22.
Dai, Y. T.、Chang, C. P.、Tu, L. J.、Hsu, D. J.(2007)。Development of a Taiwanese Head Model for Studying Occupational Particle Exposure。Inhalation Toxicology,19,383-392。
23.
Häußermann, S.、Bailey, A. G.、Bailey, M. R.、Etherington, G.、Youngman, M.(2002)。The influence of breathing patterns on particle deposition in a nasal replicate cast。Journal of Aerosol Science,33,923-933。
24.
Cheng, Y. S.(2003)。Aerosol Deposition in the Extrathoracic Region。Aerosol Science and Technology,37,659-671。
推文
當script無法執行時可按︰
推文
推薦
當script無法執行時可按︰
推薦
引用網址
當script無法執行時可按︰
引用網址
引用嵌入語法
當script無法執行時可按︰
引用嵌入語法
轉寄
當script無法執行時可按︰
轉寄
top
:::
相關期刊
相關論文
相關專書
相關著作
熱門點閱
無相關期刊論文
無相關博士論文
無相關書籍
無相關著作
1.
美海軍「空氣潛水減壓」程序應用探討
2.
連續進料CNC機臺加裝油霧回收機之細菌生物氣膠移除效能評估
3.
美國勞工部職業安全衛生署依各種法律反報復條款下專屬保護吹哨者之制度
4.
Reduction of Cooking Oil Fume Exposure by Engineering Intervention in Chinese Restaurants
5.
影印機為火災起火源之可能性分析
6.
以細胞株直接暴露系統應用於評估燃燒產物細胞毒性
7.
環保矽酸鈣板製造、使用之粉塵及重金屬暴露調查
8.
長短期失能個案居家物理治療服務利用與療效--以臺北都會區為例
9.
殺蟲劑應用於登革熱防疫之成本效用分析:以高雄市為例
10.
花蓮地區長期照顧家庭主要照顧者時間貨幣價值之探討--福康評估法之應用
11.
評論:評估地區相對極端氣溫的天氣型態對臺灣七大空品區居民健康之影響--以腦血管疾病及缺血性心臟病為例
QR Code