This article describes the nursing experience of a patient wounded and infected with vibrio vulnifi cus, which led to necrotizing fasciitis. By using Roy's adaptation model, the major problems were identifi ed as existing infection, pain, and hopelessness. Early care prioritizes wound infection and pain; in addition to wound care for the patient, infection prevention measures and guidance for pain relief techniques were provided. Furthermore, we listened to the patient with empathy and helped the patient to understand the current body conditions to increase the patient's sense of control. Eventually, the infection was controlled, wound healing was improved, and the patient's pain was alleviated, enabling the patient to overcome the feeling of hopelessness.