Under the impact of globalization, the movement of money, goods, people and information across borders became more prevalent. At the same time, dramatic advances in technology, notably in the internet and communications technologies, heightened cross-border linkages and made national frontiers seem more permeable than ever. According to the data revealed by government and non-government organizations, transnational crimes have increased significantly in Taiwan. Transnational crimes not only create serious economic cost, but also lead to substantial harm on social security and the human rights. Literature reveals that there are diverse types of transnational crimes, such as transnational fraud, drug trafficking, human trafficking, money laundering and so on. Besides, the damage of transnational crime is enormous. Since this type of crime across border and such criminal activities are occult and sophisticated so that results in low clearance rate. Victims of transnational crimes usually express low satisfaction with criminal justice system. Transnational crime produces tremendous damage and leads to low clearance rate, therefore, the international intelligence exchange for detecting and preventing transnational crime is obviously important. The purpose of this article is to explore the operation and challenges of international intelligence exchange systems, such as global, regional and bilateral law enforcement cooperation system. Finally, this paper also provides clues for law enforcement on how to enhance the quality of intelligence exchange.