目的：影響安全績效前置因素為領導者的支持及態度，有效的領導行為是建置組織中優良安全態度與文化的重要推手，同時安全態度與文化亦是影響安全績效的決定因素。因此，本研究嘗試藉由調查測量領導風格、安全態度與安全績效之關聯性，並驗證安全態度在領導風格與安全績效兩者間是具有中介效果。方法：採橫斷性研究等比機率抽樣，針對臺灣東部某醫學中心醫事人員為對象進行結構式問卷調查。以描述性統計、推論性統計與結構方程模型分析各變項間關聯性。結果：安全態度對安全績效為顯著正向影響（路徑係數=0.46，p＜0.001）；領導風格對安全績效無顯著影響（路徑係數=0.01，p＞0.05），安全態度具完全中介效果。結論：衛生主管機關與醫療院所領導者需重視安全態度建構前置因素，以提升整體醫療照護品質。

Objectives: Leadership support and positive attitudes are prerequisites for safe performance; therefore, effective leadership behaviors are essential in building a positive attitude and a culture ofoutstanding organizational safety. Positive attitudes and a culture of safety are also decisive factors in safe performance. The aims of this study were to investigate the relationships among leadership style, attitudes about safety, and safe performance, and to determine if there was a mediating effect of attitudes about safety between leadership style and safe performance. Methods: This was a cross-sectional study, and a probability sample of subjects was surveyed with a structured questionnaire. Subjects were medical personnel from a medical center in eastern Taiwan. Data were analyzed with descriptive statistics, inferential statistics, and structural equation models. Results: In the mediation analysis, attitude about safety was significantly positively associated with safe performance (path coefficient=0.46, p＜0.001), but leadership style had no significant association with safe performance (path coefficient=0.01, p＞0.05). Conclusions: A positive attitude about safety promotes a safe hospital environment, and improves the overall quality of healthcare.