Along with the digitization of the bank, the bank is not only providing financial services via entities branches, but also combination of internet banking and smart phone APP to provide more convenient services. The development of internet banking and mobile payment pattern has reached a mature phase in Taiwan, which provides the third-party payment business for the bank a favorable environment. Third-party payment has become the focus of the development of e-commerce. The third-party payment platform integrates a large number of users with the electronic money. It is the important foundation of internet banking. It will become the first choice of customers on internet bank and mobile payment. This study summarized risks and potential business opportunities of third-party payment service of bank development from literatures. Based on three dimensions of legislation, market, cash flow and twelve factors, expert questionnaires are issued. The Decision Making and Trail Evaluation Laboratory (DEMATEL) is applied to analyze the data of questionnaires, and the weight of the relationship between the criterion and the sub-criteria, is evaluated to find out the determinant factor of bank undertaking third-party payment business decision. The benefits and the potential expansion of business are expected to be proposed further to be the business decision-making reference for banks.