In order to understand the slope stability at different geological conditions affected by rainfall, this research investigates the colluvium slope located at 86k+950 milestone of Ali Mountain Highway in Chiayi Country, the alternating sandstone and shale slope located at 52k+150 milestone of Southern Cross-Island Highway in Tainan City and the shale slope located at 01k+800 milestone of Tengchih Forest Road in Kaohsiung City as the targets for research. These three sites are located at the important traffic road at southern Taiwan. The site stratum sample was collected for laboratory tests to understand the stratum distribution of slope along with its physical properties and mechanics characteristics. Also, a permeation test had been done to understand the permeability of slope body of different lithological properties. The borehole drilling, water well, inclinometers, electrical resistivity tomography test were adopted to generate the stratum model of each test slope, and this monitoring system was established to observe the location and the behavior of the possible sliding plane. Furthermore, the relationship between the change of underground water level and the stability of slope was explored. Then, the rainfall, the underground water influctuation and the stability of slope of the three trial slopes were integrated to establish of a slope failure pre-warning system.