| 期刊論文| 1. | DeFronzo, R. A.(1992)。Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus a balanced overview。Diabetologia，35(4)，389-397。   | | 2. | Hu, F. B.、Sigal, R. J.、Rich-Edwards, J. W.、Colditz, G. A.、Solomon, C. G.、Willett, W. C.、Manson, J. E.(1999)。Walking compared with vigorous physical activity and risk of type 2 diabetes in women, a prospective study。The Journal of the American Medical Association，282(15)，1433-1439。 | | 3. | Lamberts, S. W. J.、Van den Beld, A. W.、Van der Lely, A. J.(1997)。The endocrinology of aging。Science，278(5337)，419-424。 | | 4. | Rommel, C.、Bodine, S. C.、Clarke, B. A.、Rossman, R.、Nunez, L.、Stitt, T. N.、Glass, D. J.(2001)。Mediation of IGF-1-induced skeletal myotube hypertrophy by PI (3) K/Akt/mTOR and PI (3) K/Akt/GSK3 pathways。Nature cell biology，3(11)，1009-1013。 | | 5. | Kuk, J. L.、Saunders, T. J.、Davidson, L. E.、Ross, R.(2009)。Age-related changes in total and regional fat distribution。Ageing Research Reviews，8(4)，339-348。 | | 6. | Stitt, T. N.、Drujan, D.、Clarke, B. A.、Panaro, F.、Timofeyva, Y.、Kline, W. O.、Glass, D. J.(2004)。The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors。Molecular Cell，14(3)，395-403。 | | 7. | Gianoudis, J.、Bailey, C. A.、Daly, R. M.(2015)。Associations between sedentary behaviour and body composition, muscle function and sarcopenia in community-dwelling older adults。Osteoporosis International，26(2)，571-579。 | | 8. | Kraemer, W. J.、Ratamess, N. A.、Nindl, B. C.(2017)。Recovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise。Journal of Applied Physiology，122(3)，549-558。 | | 9. | Ghaben, A. L.、Scherer, P. E.(2019)。Adipogenesis and metabolic health。Nature Reviews Molecular Cell Biology，20(4)，242-258。 | | 10. | Fuster, J. J.、Ouchi, N.、Gokce, N.、Walsh, K.(2016)。Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease。Circulation Research，118(11)，1786-1807。 | | 11. | Buch, A.、Carmeli, E.、Boker, L. K.、Marcus, Y.、Shefer, G.、Kis, O.、Stern, N.(2016)。Muscle function and fat content in relation to sarcopenia, obesity and frailty of old age--An overview。Experimental Gerontology，76，25-32。 | | 12. | Sakamoto, K.、Holman, G. D.(2008)。Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic。American Journal of Physiology Endocrinology and Metabolism，295(1)，E29-E37。 | | 13. | Anantharaju, A.、Feller, A.、Chedid, A.(2002)。Aging Liver。Gerontology，48(6)，343-353。 | | 14. | Arthur, J. S. C.、Ley, S. C.(2013)。Mitogen-activated protein kinases in innate immunity。Nature Reviews Immunology，13(9)，679-692。 | | 15. | Bruunsgaard, H.、Skinhøj, P.、Pedersen, A. N.、Schroll, M.、Pedersen, B. K.(2000)。Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis。Clinical and experimental immunology，121(2)，255-260。 | | 16. | Čejková, S.、Králová-Lesná, I.、Poledne, R.(2016)。Monocyte adhesion to the endothelium is an initial stage of atherosclerosis development。Cor et Vasa，58(4)，e419-e425。 | | 17. | Chatterjee, T.、De, D.、Chowdhury, S.、Bhattacharyya, M.(2020)。Nuclear factor NF-κB1 functional promoter polymorphism and its expression conferring the risk of Type 2 diabetes-associated dyslipidemia。Mammalian Genome，31(7/8)，252-262。 | | 18. | Chen, L.、Chen, R.、Wang, H.、Liang, F.(2015)。Mechanisms Linking Inflammation to Insulin Resistance。International Journal of Endocrinology，2015。 | | 19. | Christian, F.、Smith, E. L.、Carmody, R. J.(2016)。The Regulation of NF-κB Subunits by Phosphorylation。Cells，5(1)。 | | 20. | Clark, M. G.、Rattigan, S.、Barrett, E. J.(2006)。Nutritive blood flow as an essential element supporting muscle anabolism。Current Opinion in Clinical Nutrition & Metabolic Care，9(3)，185-189。 | | 21. | Dasu, M. R.、Devaraj, S.、Zhao, L.、Hwang, D. H.、Jialal, I.(2008)。High Glucose Induces Toll-Like Receptor Expression in Human Monocytes。Mechanism of Activation，57(11)，3090-3098。 | | 22. | Dasu, M. R.、Devaraj, S.、Park, S.、Jialal, I.(2010)。Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects。Diabetes Care，33(4)，861-868。 | | 23. | DeFronzo, R. A.、Gunnarsson, R.、Björkman, O.、Olsson, M.、Wahren, J.(1985)。Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus。The Journal of clinical investigation，76(1)，149-155。 | | 24. | Dunlop, E. A.、Tee, A. R.(2014)。mTOR and autophagy: a dynamic relationship governed by nutrients and energy。Seminars in Cell & Developmental Biology，36，121-129。 | | 25. | Durrer, C.、Lewis, N.、Wan, Z.、Ainslie, P. N.、Jenkins, N. T.、Little, J. P.(2019)。Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis。Nutrients，11(3)。 | | 26. | Erion, D. M.、Shulman, G. I.(2010)。Diacylglycerol-mediated insulin resistance。Nature Medicine，16(4)，400-402。 | | 27. | Fadini, G. P.、De Kreutzenberg, S. V.、Boscaro, E.、Albiero, M.、Cappellari, R.、Kränkel, N.、Avogaro, A.(2013)。An unbalanced monocyte polarisation in peripheral blood and bone marrow of patients with type 2 diabetes has an impact on microangiopathy。Diabetologia，56(8)，1856-1866。 | | 28. | Gonzalez, A. M.、Hoffman, J. R.、Stout, J. R.、Fukuda, D. H.、Willoughby, D. S.(2016)。Intramuscular Anabolic Signaling and Endocrine Response Following Resistance Exercise: Implications for Muscle Hypertrophy。Sports Medicine，46(5)，671-685。 | | 29. | Hornberger, T.、Chu, W.、Mak, Y.、Hsiung, J.、Huang, S.、Chien, S.(2006)。The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle。Proceedings of the National Academy of Sciences，103(12)，4741-4746。 | | 30. | He, L.、Wong, C. K.、Cheung, K. K.、Yau, H. C.、Fu, A.、Zhao, H. L.、Chan, J. C.(2013)。Anti-inflammatory effects of exendin-4, a glucagon-like peptide-1 analog, on human peripheral lymphocytes in patients with type 2 diabetes。Journal of Diabetes Investigation，4(4)，382-392。 | | 31. | Horvath, P.、Oliver, S. R.、Ganesan, G.、Zaldivar, F. P. Jr.、Radom-Aizik, S.、Galassetti, P. R.(2013)。Fasting glucose level modulates cell surface expression of CD11b and CD66b in granulocytes and monocytes of patients with type 2 diabetes。Journal of Investigative Medicine，61(6)，972-977。 | | 32. | Hwang, D. H.、Kim, J. A.、Lee, J. Y.(2016)。Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid。European Journal of Pharmacology，785，24-35。 | | 33. | Jewell, J. L.、Guan, K.-L.(2013)。Nutrient Signaling to mTOR and Cell Growth。Trends in biochemical sciences，38(5)，233-242。 | | 34. | Johannsen, D. L.、DeLany, J. P.、Frisard, M. I.、Welsch, M. A.、Rowley, C. K.、Fang, X.、Ravussin, E.(2008)。Physical activity in aging: comparison among young, aged, and nonagenarian individuals。Journal of Applied Physiology，105(2)，495-501。 | | 35. | Johnstone, A. M.、Murison, S. D.、Duncan, J. S.、Rance, K. A.、Speakman, J. R.(2005)。Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine。The American journal of clinical nutrition，82(5)，941-948。 | | 36. | Kaaman, M.、Sparks, L. M.、Van Harmelen, V.、Smith, S. R.、Sjölin, E.、Dahlman, I.、Arner, P.(2007)。Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue。Diabetologia，50(12)，2526-2533。 | | 37. | Koehler, E. M.、Schouten, J. N.、Hansen, B. E.、Van Rooij, F. J.、Hofman, A.、Stricker, B. H.、Janssen, H. L.(2012)。Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: results from the Rotterdam study。Journal of Hepatology，57(6)，1305-1311。 | | 38. | Kuzmicki, M.、Telejko, B.、Wawrusiewicz-Kurylonek, N.、Lipinska, D.、Pliszka, J.、Wilk, J.、Gorska, M.(2013)。The expression of genes involved in NF-κB activation in peripheral blood mononuclear cells of patients with gestational diabetes。European Journal of Endocrinology，168(3)，419-427。 | | 39. | Liang, H.、Lum, H.、Alvarez, A.、Garduno-Garcia, J. J.、Daniel, B. J.、Musi, N.(2018)。A low dose lipid infusion is sufficient to induce insulin resistance and a pro-inflammatory response in human subjects。PLoS One，13(4)，0195810。 | | 40. | Lo, Y. T.、Wahlqvist, M. L.、Huang, Y. C.、Lee, M. S.(2016)。Elderly Taiwanese who spend more on fruits and vegetables and less on animal-derived foods use less medical services and incur lower medical costs。British Journal of Nutrition，115(5)，823-833。 | | 41. | Mevorach, M.、Giacca, A.、Aharon, Y.、Hawkins, M.、Shamoon, H.、Rossetti, L.(1998)。Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus。Journal of Clinical Investigation，102(4)，744-753。 | | 42. | Miquel, J.(2009)。An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging。Current pharmaceutical design，15(26)，3003-3026。 | | 43. | Ocaranza, M. P.、Valderas, P.、Moya, J.、Gabrielli, L.、Godoy, I.、Córdova, S.、Jalil, J. E.(2020)。Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2。Cardiovascular Diabetology，19(1)。 | | 44. | Park, S. Y.、Lee, S. W.、Lee, S. Y.、Hong, K. W.、Bae, S. S.、Kim, K.、Kim, C. D.(2017)。SIRT1/Adenosine Monophosphate-Activated Protein Kinase α Signaling Enhances Macrophage Polarization to an Anti-inflammatory Phenotype in Rheumatoid Arthritis。Frontiers in Immunology，8(1135)。 | | 45. | Perseghin, G.、Scifo, P.、De Cobelli, F.、Pagliato, E.、Battezzati, A.、Arcelloni, C.、Del Maschio, A.(1999)。Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents。Diabetes，48(8)，1600-1606。 | | 46. | Poehlman, E.、Berke, E.、Joseph, J.、Gardner, A.、Katzman-Rooks, S.、Goran, M.(1992)。Influence of aerobic capacity, body composition, and thyroid hormones on the age-related decline in resting metabolic rate。Metabolism，41(8)，915-921。 | | 47. | Proud, C. G.(2009)。mTORC1 signalling and mRNA translation。Biochemical Society Transactions，37(Pt 1)，227-231。 | | 48. | Riera-Borrull, M.、Cuevas, V. D.、Alonso, B.、Vega, M. A.、Joven, J.、Izquierdo, E.、Corbi, A. L.(2017)。Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation。Journal of Immunology，199(11)，3858-3869。 | | 49. | Rodriguez-Miguelez, P.、Fernandez-Gonzalo, R.、Almar, M.、Mejias, Y.、Rivas, A.、De Paz, J. A.、Gonzalez-Gallego, J.(2014)。Role of Toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects。Age (Dordr)，36(6)。 | | 50. | Sadeghabadi, Z. A.、Ziamajidi, N.、Abbasalipourkabir, R.、Mohseni, R.、Borzouei, S.(2019)。Palmitate-induced IL6 expression ameliorated by chicoric acid through AMPK and SIRT1-mediated pathway in the PBMCs of newly diagnosed type 2 diabetes patients and healthy subjects。Cytokine，116，106-114。 | | 51. | Schiekofer, S.、Andrassy, M.、Chen, J.、Rudofsky, G.、Schneider, J.、Wendt, T.、Bierhaus, A.(2003)。Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs。Diabetes，52(3)，621-633。 | | 52. | Shi, J. H.、Sun, S. C.(2018)。Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways。Frontiers in Immunology，9。 | | 53. | Shimabukuro, M.、Zhou, Y. T.、Levi, M.、Unger, R. H.(1998)。Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes。Proceedings of the National Academy of Sciences，95(5)，2498-2502。 | | 54. | Sindhu, S.、Kochumon, S.、Shenouda, S.、Wilson, A.、Al-Mulla, F.、Ahmad, R.(2019)。The Cooperative Induction of CCL4 in Human Monocytic Cells by TNF-α and Palmitate Requires MyD88 and Involves MAPK/NF-κB Signaling Pathways。International Journal of Molecular Sciences，20(18)。 | | 55. | Slawik, M.、Vidal-Puig, A. J.(2006)。Lipotoxicity, overnutrition and energy metabolism in aging。Ageing research reviews，5(2)，144-164。 | | 56. | Szczepaniak, L. S.、Victor, R. G.、Mathur, R.、Nelson, M. D.、Szczepaniak, E. W.、Tyer, N.、Lingvay, I.(2012)。Pancreatic steatosis and its relationship to β-cell dysfunction in humans: racial and ethnic variations。Diabetes Care，35(11)，2377-2383。 | | 57. | Tchaikovski, V.、Olieslagers, S.、Böhmer, F. D.、Waltenberger, J.(2009)。Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes。Circulation，120(2)，150-159。 | | 58. | Timmerman, K. L.、Lee, J. L.、Dreyer, H. C.、Dhanani, S.、Glynn, E. L.、Fry, C. S.、Volpi, E.(2010)。Insulin Stimulates Human Skeletal Muscle Protein Synthesis via an Indirect Mechanism Involving Endothelial-Dependent Vasodilation and Mammalian Target of Rapamycin Complex 1 Signaling。The Journal of Clinical Endocrinology & Metabolism，95(8)，3848-3857。 | | 59. | Volpi, E.、Mittendorfer, B.、Wolf, S. E.、Wolfe, R. R.(1999)。Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction。American Journal of Physiology-Endocrinology and Metabolism，277(3)，513-520。 | | 60. | Walker, A.、Nissen, E.、Geiger, A.(2018)。Migratory, metabolic and functional alterations of fibrocytes in type 2 diabetes。IUBMB Life，70(11)，1122-1132。 | | 61. | Wan, Z.、Durrer, C.、Mah, D.、Simtchouk, S.、Robinson, E.、Little, J. P.(2014)。Reduction of AMPK activity and altered MAPKs signalling in peripheral blood mononuclear cells in response to acute glucose ingestion following a shortterm high fat diet in young healthy men。Metabolism，63(9)，1209-1216。 | | 62. | Weinsier, R. L.、Schutz, Y.、Bracco, D.(1992)。Reexamination of the relationship of resting metabolic rate to fat-free mass and to the metabolically active components of fat-free mass in humans。The American journal of clinical nutrition，55(4)，790-794。 | | 63. | Wolfe, R. R.(2006)。Skeletal Muscle Protein Metabolism and Resistance Exercise。The Journal of Nutrition，136(2)，525S-528S。 | | 64. | Yi, B.、Hu, X.、Zhang, H.、Huang, J.、Liu, J.、Hu, J.、Huang, L.(2014)。Nuclear NF-κB p65 in peripheral blood mononuclear cells correlates with urinary MCP-1, RANTES and the severity of type 2 diabetic nephropathy。PLoS One，9(6)。 | | 65. | Zhu, T.、Meng, Q.、Ji, J.、Zhang, L.、Lou, X.(2017)。TLR4 and Caveolin-1 in Monocytes Are Associated With Inflammatory Conditions in Diabetic Neuropathy。Clinical and Translational Science，10(3)，178-184。 | 研究報告| 1. | 行政院衛福部(2019)。107年國人死因統計結果。 延伸查詢 | 圖書| 1. | Farrell, P. A.、Joyner, M. J.、Caiozzo, V.(2011)。ACSM's advanced exercise physiology。Wolters Kluwer Health Adis (ESP)。 | 其他| 1. | 行政院衛福部(2019)。2018國民健康署年報，https://www.hpa.gov.tw/Pages/ashx/File.ashx?FilePath=~/File/Attach/10284/File_11722.pdf。 | | 2. | 行政院國發會(2020)。中華民國人口推估，https://popproj.ndc.gov.tw/dataSearch.aspx?uid=3109&pid=59。 延伸查詢 | |